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3GJD
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BU of 3gjd by Molmil
Crystal Structure of LeuT with bound OG
Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GJC
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BU of 3gjc by Molmil
Crystal Structure of the E290S mutant of LeuT with bound OG
Descriptor: LEUCINE, SODIUM ION, Transporter, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
4US4
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BU of 4us4 by Molmil
Crystal Structure of the Bacterial NSS Member MhsT in an Occluded Inward-Facing State (lipidic cubic phase form)
Descriptor: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, SODIUM ION, ...
Authors:Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P.
Deposit date:2014-07-02
Release date:2014-09-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters
Nat.Struct.Mol.Biol., 21, 2014
5K5T
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BU of 5k5t by Molmil
Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ...
Authors:Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
8FT5
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BU of 8ft5 by Molmil
Crystal structure of LeuT soaked with Crown-5
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
Deposit date:2023-01-11
Release date:2023-11-22
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
8FT4
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BU of 8ft4 by Molmil
Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
Deposit date:2023-01-11
Release date:2023-11-22
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
4F12
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BU of 4f12 by Molmil
Crystal structure of the extracellular domain of human GABA(B) receptor GBR2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 2
Authors:Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R.
Deposit date:2012-05-05
Release date:2012-06-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Nat.Neurosci., 15, 2012
4F11
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BU of 4f11 by Molmil
Crystal structure of the extracellular domain of human GABA(B) receptor GBR2
Descriptor: Gamma-aminobutyric acid type B receptor subunit 2
Authors:Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R.
Deposit date:2012-05-05
Release date:2012-06-06
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Nat.Neurosci., 15, 2012
4US3
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BU of 4us3 by Molmil
Crystal Structure of the bacterial NSS member MhsT in an Occluded Inward-Facing State
Descriptor: DODECYL-ALPHA-D-MALTOSIDE, SODIUM ION, TRANSPORTER, ...
Authors:Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P.
Deposit date:2014-07-02
Release date:2014-09-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters
Nat.Struct.Mol.Biol., 21, 2014
5K5S
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BU of 5k5s by Molmil
Crystal structure of the active form of human calcium-sensing receptor extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ...
Authors:Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
4HMK
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BU of 4hmk by Molmil
Crystal structure of LeuT-E290S with bound Br
Descriptor: BROMIDE ION, LEUCINE, SODIUM ION, ...
Authors:Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P.
Deposit date:2012-10-18
Release date:2013-05-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:The chloride binding site of Neurotransmitter Sodium Symporters
Proc.Natl.Acad.Sci.USA, 2013
4HOD
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BU of 4hod by Molmil
Crystal structure of LeuT-E290S with bound Cl
Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ...
Authors:Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P.
Deposit date:2012-10-22
Release date:2013-05-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The chloride binding site of Neurotransmitter Sodium Symporters
Proc.Natl.Acad.Sci.USA, 2013
6YU2
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BU of 6yu2 by Molmil
Crystal structure of MhsT in complex with L-isoleucine
Descriptor: ISOLEUCINE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6WIV
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BU of 6wiv by Molmil
Structure of human GABA(B) receptor in an inactive state
Descriptor: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Park, J, Fu, Z, Frangaj, A, Liu, J, Mosyak, L, Shen, T, Slavkovich, V.N, Ray, K.M, Taura, J, Cao, B, Geng, Y, Zuo, H, Kou, Y, Grassucci, R, Chen, S, Liu, Z, Lin, X, Williams, J.P, Rice, W.J, Eng, E.T, Huang, R.K, Soni, R.K, Kloss, B, Yu, Z, Javitch, J.A, Hendrickson, W.A, Slesinger, P.A, Quick, M, Graziano, J, Yu, H, Fiehn, O, Clarke, O.B, Frank, J, Fan, Q.R.
Deposit date:2020-04-10
Release date:2020-07-01
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of human GABABreceptor in an inactive state.
Nature, 584, 2020
6YU6
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BU of 6yu6 by Molmil
Crystal structure of MhsT in complex with L-leucine
Descriptor: DODECYL-BETA-D-MALTOSIDE, LEUCINE, SODIUM ION, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU4
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BU of 6yu4 by Molmil
Crystal structure of MhsT in complex with L-4F-phenylalanine
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4-FLUORO-L-PHENYLALANINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU5
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BU of 6yu5 by Molmil
Crystal structure of MhsT in complex with L-valine
Descriptor: DODECYL-BETA-D-MALTOSIDE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU7
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BU of 6yu7 by Molmil
Crystal structure of MhsT in complex with L-tyrosine
Descriptor: DODECYL-BETA-D-MALTOSIDE, SODIUM ION, Sodium-dependent transporter, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6YU3
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BU of 6yu3 by Molmil
Crystal structure of MhsT in complex with L-phenylalanine
Descriptor: DODECYL-BETA-D-MALTOSIDE, GLYCEROL, PHENYLALANINE, ...
Authors:Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P.
Deposit date:2020-04-25
Release date:2020-07-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Embo J., 40, 2021
6UKJ
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BU of 6ukj by Molmil
Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform
Descriptor: CHOLESTEROL HEMISUCCINATE, Chloroquine resistance transporter, Fab Heavy Chain, ...
Authors:Kim, J, Tan, Y.Z, Wicht, K.J, Erramilli, S.K, Dhingra, S.K, Okombo, J, Vendome, J, Hagenah, L.M, Giacometti, S.I, Warren, A.L, Nosol, K, Roepe, P.D, Potter, C.S, Carragher, B, Kossiakoff, A.A, Quick, M, Fidock, D.A, Mancia, F.
Deposit date:2019-10-05
Release date:2019-12-04
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature, 576, 2019
8SHC
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BU of 8shc by Molmil
Pendrin in complex with Niflumic acid
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, CHLORIDE ION, ...
Authors:Wang, L, Hoang, A, Zhou, M.
Deposit date:2023-04-13
Release date:2024-02-07
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
8SIE
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BU of 8sie by Molmil
Pendrin in complex with bicarbonate
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, BICARBONATE ION, CHOLESTEROL, ...
Authors:Wang, L, Hoang, A, Zhou, M.
Deposit date:2023-04-16
Release date:2024-02-07
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
8SH3
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BU of 8sh3 by Molmil
Pendrin in complex with iodide
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, IODIDE ION, ...
Authors:Wang, L, Hoang, A, Zhou, M.
Deposit date:2023-04-13
Release date:2024-02-07
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
8SGW
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BU of 8sgw by Molmil
Pendrin in complex with chloride
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHLORIDE ION, CHOLESTEROL, ...
Authors:Wang, L, Hoang, A, Zhou, M.
Deposit date:2023-04-13
Release date:2024-02-07
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
8UUK
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BU of 8uuk by Molmil
Pendrin in apo
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Lauryl Maltose Neopentyl Glycol, ...
Authors:Wang, L, Hoang, A, Zhou, M.
Deposit date:2023-11-01
Release date:2024-02-07
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024

 

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