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6OQM
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BU of 6oqm by Molmil
crystal structure of the MSH6 PWWP domain
Descriptor: DNA mismatch repair protein Msh6, MAGNESIUM ION, SULFATE ION, ...
Authors:Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-26
Release date:2019-05-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:crystal structure of the MSH6 PWWP domain
To Be Published
4FU6
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BU of 4fu6 by Molmil
Crystal structure of the PSIP1 PWWP domain
Descriptor: GLYCEROL, PC4 and SFRS1-interacting protein, SULFATE ION, ...
Authors:Qin, S, Tempel, W, Xu, C, Wu, H, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2012-06-28
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of the nucleosome-binding PWWP domain.
Trends Biochem.Sci., 39, 2014
4HAE
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BU of 4hae by Molmil
Crystal structure of the CDYL2-chromodomain
Descriptor: Chromodomain Y-like protein 2, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Qin, S, Dombrovski, L, Tempel, W, Dong, A, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-09-26
Release date:2012-10-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the CDYL2-chromodomain
To be Published
2KU3
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BU of 2ku3 by Molmil
Solution structure of BRD1 PHD1 finger
Descriptor: Bromodomain-containing protein 1, ZINC ION
Authors:Qin, S, Zhang, J, Wu, J, Shi, Y.
Deposit date:2010-02-12
Release date:2011-02-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of BRD1 PHD1 finger
To be Published
2L43
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BU of 2l43 by Molmil
Structural basis for histone code recognition by BRPF2-PHD1 finger
Descriptor: Histone H3.3,LINKER,Bromodomain-containing protein 1, ZINC ION
Authors:Qin, S, Zhang, J, Wu, J, Shi, Y.
Deposit date:2010-10-01
Release date:2011-08-31
Last modified:2020-01-15
Method:SOLUTION NMR
Cite:Recognition of unmodified histone H3 by the first PHD finger of Bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases MOZ and MORF
To be Published
4NW2
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BU of 4nw2 by Molmil
Tandem chromodomains of human CHD1 in complex with Influenza virus NS1 C-terminal tail trimethylated at K229
Descriptor: Chromodomain-helicase-DNA-binding protein 1, GLYCEROL, Nonstructural protein 1, ...
Authors:Qin, S, Tempel, W, Xu, C, El Bakkouri, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-05
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
4O45
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BU of 4o45 by Molmil
WDR5 in complex with influenza NS1 C-terminal tail
Descriptor: Nonstructural protein 1, UNKNOWN ATOM OR ION, WD repeat-containing protein 5
Authors:Qin, S, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-18
Release date:2014-04-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
4O46
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BU of 4o46 by Molmil
14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228
Descriptor: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ...
Authors:Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-18
Release date:2014-04-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
4O42
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BU of 4o42 by Molmil
Tandem chromodomains of human CHD1 in complex with influenza NS1 C-terminal tail dimethylated at K229
Descriptor: Chromodomain-helicase-DNA-binding protein 1, GLYCEROL, Nonstructural protein 1, ...
Authors:Qin, S, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-18
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
6CKN
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BU of 6ckn by Molmil
Crystal structure of an AF10 fragment
Descriptor: Protein AF-10, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-02-28
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6V3N
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BU of 6v3n by Molmil
Crystal structure of CDYL2 in complex with H3K27me3
Descriptor: ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, Chromodomain Y-like protein 2, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-26
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V41
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BU of 6v41 by Molmil
crystal structure of CDY1 chromodomain bound to H3K9me3
Descriptor: Histone H3.1 Peptide, Testis-specific chromodomain protein Y 1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-27
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
2MJ8
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BU of 2mj8 by Molmil
Solution structure of CDYL2 chromodomain
Descriptor: Chromodomain Y-like protein 2
Authors:Qin, S, Houliston, S, Arrowsmith, C.H, Edwards, A.M, Wu, H, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-28
Release date:2014-04-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6BHG
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BU of 6bhg by Molmil
Crystal structure of SETDB1 with a modified H3 peptide
Descriptor: Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHI
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BU of 6bhi by Molmil
Crystal structure of SETDB1 with a modified H3 peptide
Descriptor: Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHD
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BU of 6bhd by Molmil
Crystal structure of SETDB1 with a modified H3 peptide
Descriptor: Histone H3.1, Histone-lysine N-methyltransferase SETDB1, SODIUM ION, ...
Authors:Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-12-06
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHH
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BU of 6bhh by Molmil
Crystal structure of SETDB1 with a modified H3 peptide
Descriptor: Histone H3.1, Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ...
Authors:Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-11-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHE
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BU of 6bhe by Molmil
Crystal structure of SETDB1 with a modified H3 peptide
Descriptor: Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
4TY9
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BU of 4ty9 by Molmil
An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline
Descriptor: 5-(trifluoromethyl)pyridin-2-amine, Polyprotein
Authors:Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S.
Deposit date:2014-07-08
Release date:2015-05-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
4TYA
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BU of 4tya by Molmil
An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline
Descriptor: 4-(trifluoromethyl)benzoic acid, Polyprotein
Authors:Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S.
Deposit date:2014-07-08
Release date:2015-05-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
4TYB
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BU of 4tyb by Molmil
An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline
Descriptor: (2R)-morpholin-4-yl(phenyl)ethanenitrile, Polyprotein
Authors:Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S.
Deposit date:2014-07-08
Release date:2015-05-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
4TXS
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BU of 4txs by Molmil
An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline
Descriptor: (4-hydroxyphenyl)acetonitrile, Polyprotein
Authors:Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S.
Deposit date:2014-07-07
Release date:2015-05-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
4TY8
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BU of 4ty8 by Molmil
An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline
Descriptor: 6-methyl-2H-chromen-2-one, Polyprotein
Authors:Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S.
Deposit date:2014-07-08
Release date:2015-05-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
7LH9
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BU of 7lh9 by Molmil
Crystal structure of BRPF2 PWWP domain in complex with DNA
Descriptor: Bromodomain-containing protein 1, DNA
Authors:Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC)
Deposit date:2021-01-21
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Biochim Biophys Acta Gene Regul Mech, 1864, 2021
6MLC
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BU of 6mlc by Molmil
PHD6 domain of MLL3 in complex with histone H4
Descriptor: GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ...
Authors:Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-10-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019

 

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