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8IJS
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BU of 8ijs by Molmil
anti-VEGF nanobody mutant
Descriptor: ZINC ION, anti-VEGF nanobody
Authors:Qian, F, Zhu, S.Q.
Deposit date:2023-02-28
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
8IIU
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BU of 8iiu by Molmil
anti-VEGF nanobody
Descriptor: SULFATE ION, anti-VEGF nanobody
Authors:Qian, F, Zhu, S.Q.
Deposit date:2023-02-24
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
8IJZ
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BU of 8ijz by Molmil
anti-VEGF mutant
Descriptor: anti-VEGF nanobody
Authors:Qian, F, Zhu, S.Q.
Deposit date:2023-02-28
Release date:2023-12-27
Method:ELECTRON CRYSTALLOGRAPHY (2.1 Å)
Cite:Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
1KD7
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BU of 1kd7 by Molmil
Crystal structure of an extracellular domain fragment of human BAFF
Descriptor: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B
Authors:Karpusas, M, Cachero, T.G, Qian, F, Boriack-Sjodin, A, Mullen, C, Strauch, K, Hsu, Y.-M, Kalled, S.L.
Deposit date:2001-11-12
Release date:2002-11-12
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Extracellular Human BAFF, a TNF Family Member that Stimulates B Lymphocytes
J.Mol.Biol., 315, 2002
3LQ8
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BU of 3lq8 by Molmil
Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)
Descriptor: Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Authors:Lougheed, J.C, Stout, T.J.
Deposit date:2010-02-08
Release date:2010-05-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases.
Cancer Res., 69, 2009
8HK7
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BU of 8hk7 by Molmil
Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, CALCIUM ION, ...
Authors:Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y.
Deposit date:2022-11-25
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
3KJ4
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BU of 3kj4 by Molmil
Structure of rat Nogo receptor bound to 1D9 antagonist antibody
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment 1D9 heavy chain, ...
Authors:Silvian, L.F.
Deposit date:2009-11-02
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering.
Biotechnol Appl Biochem, 57, 2010
4AW5
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BU of 4aw5 by Molmil
Complex of the EphB4 kinase domain with an oxindole inhibitor
Descriptor: (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one, EPHRIN TYPE-B RECEPTOR 4
Authors:Till, J.H, Stout, T.J.
Deposit date:2012-05-31
Release date:2012-08-01
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The Design, Synthesis, and Biological Evaluation of Potent Receptor Tyrosine Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
3LKJ
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BU of 3lkj by Molmil
Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism
Descriptor: (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand
Authors:Silvian, L.F, Whitty, A.
Deposit date:2010-01-27
Release date:2011-02-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.
Acs Chem.Biol., 6, 2011
6L5M
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BU of 6l5m by Molmil
Crystal structure of human DEAD-box RNA helicase DDX21 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Nucleolar RNA helicase 2
Authors:Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X.
Deposit date:2019-10-24
Release date:2020-06-17
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
6L5L
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BU of 6l5l by Molmil
Crystal structure of human DEAD-box RNA helicase DDX21 at apo state
Descriptor: MAGNESIUM ION, Nucleolar RNA helicase 2
Authors:Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X.
Deposit date:2019-10-24
Release date:2020-06-17
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
6L5N
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BU of 6l5n by Molmil
Crystal structure of human DEAD-box RNA helicase DDX21 at post-unwound state
Descriptor: MAGNESIUM ION, Nucleolar RNA helicase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X.
Deposit date:2019-10-24
Release date:2020-06-17
Last modified:2020-08-12
Method:X-RAY DIFFRACTION (2.242 Å)
Cite:Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
6L5O
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BU of 6l5o by Molmil
Crystal structure of human DEAD-box RNA helicase DDX21 at post-hydrolysis state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X.
Deposit date:2019-10-24
Release date:2020-06-17
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Adv Sci, 7, 2020
6CO3
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BU of 6co3 by Molmil
aducanumab abeta complex
Descriptor: ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ...
Authors:Arndt, J.W.
Deposit date:2018-03-10
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.384 Å)
Cite:Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
6CNR
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BU of 6cnr by Molmil
aducanumab apo Fab
Descriptor: Aducanumab heavy chain, Aducanumab light chain, SULFATE ION
Authors:Arndt, J.W.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
2BDN
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BU of 2bdn by Molmil
Crystal structure of human MCP-1 bound to a blocking antibody, 11K2
Descriptor: Antibody heavy chain 11K2, Antibody light chain 11K2, Small inducible cytokine A2
Authors:Boriack-Sjodin, P.A, Rushe, M, Reid, C, Jarpe, M, van Vlijmen, H, Bailly, V.
Deposit date:2005-10-20
Release date:2006-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody.
Protein Eng.Des.Sel., 19, 2006
6AR4
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BU of 6ar4 by Molmil
Crystal structure of PICK1 in complex with the small molecule inhibitor 1o
Descriptor: N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine, PRKCA-binding protein
Authors:Marcotte, D.
Deposit date:2017-08-21
Release date:2018-08-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.
Sci Rep, 8, 2018
2X6L
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BU of 2x6l by Molmil
X-ray Structure of Macrophage Inflammatory Protein-1 beta
Descriptor: C-C MOTIF CHEMOKINE 4, GLYCEROL
Authors:Guo, Q, Ren, M, Tang, W.
Deposit date:2010-02-17
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
2X69
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BU of 2x69 by Molmil
X-ray Structure of Macrophage Inflammatory Protein-1 alpha polymer
Descriptor: C-C MOTIF CHEMOKINE 3
Authors:Guo, Q, Ren, M, Tang, W.
Deposit date:2010-02-15
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
2X6G
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BU of 2x6g by Molmil
X-ray Structure of Macrophage Inflammatory Protein-1 alpha (D27A)
Descriptor: C-C MOTIF CHEMOKINE 3
Authors:Guo, Q, Ren, M, Tang, W.
Deposit date:2010-02-17
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Polymerization of Mip-1 Chemokine (Ccl3 and Ccl4) and Clearance of Mip-1 by Insulin-Degrading Enzyme.
Embo J., 29, 2010
7CK1
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BU of 7ck1 by Molmil
Crystal structure of arabidopsis CESA3 catalytic domain
Descriptor: Cellulose synthase A catalytic subunit 3 [UDP-forming],Cellulose synthase A catalytic subunit 3 [UDP-forming], MANGANESE (II) ION
Authors:Qiao, Z, Gao, Y.G.
Deposit date:2020-07-15
Release date:2021-03-17
Last modified:2021-03-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
7CK3
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BU of 7ck3 by Molmil
Crystal structure of Arabidopsis CESA3 catalytic domain
Descriptor: Cellulose synthase A catalytic subunit 3 [UDP-forming],Cellulose synthase A catalytic subunit 3 [UDP-forming]
Authors:Qiao, Z, Gao, Y.G.
Deposit date:2020-07-15
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
7CK2
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BU of 7ck2 by Molmil
Crystal structure of Arabidopsis CESA3 catalytic domain with UDP-Glucose
Descriptor: Cellulose synthase A catalytic subunit 3 [UDP-forming],Cellulose synthase A catalytic subunit 3 [UDP-forming], MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Qiao, Z, Gao, Y.G.
Deposit date:2020-07-15
Release date:2021-03-17
Last modified:2021-03-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021

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