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1CVS
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BU of 1cvs by Molmil
CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
Descriptor: FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
Authors:Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M.
Deposit date:1999-08-24
Release date:2000-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1EV2
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BU of 1ev2 by Molmil
CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Descriptor: PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
Authors:Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
Deposit date:2000-04-19
Release date:2000-05-31
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EVT
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BU of 1evt by Molmil
CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
Descriptor: PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
Authors:Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
Deposit date:2000-04-20
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1IHK
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BU of 1ihk by Molmil
CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)
Descriptor: GLIA-ACTIVATING FACTOR, PHOSPHATE ION
Authors:Plotnikov, A.N, Eliseenkova, A.V, Ibrahimi, O.A, Lemmon, M.A, Mohammadi, M.
Deposit date:2001-04-19
Release date:2001-05-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition.
J.Biol.Chem., 276, 2001
4N3W
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BU of 4n3w by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with Acetylated Histone 4 Peptide (H4K20ac).
Descriptor: CREB-binding protein, Histone H4 peptide, ZINC ION
Authors:Plotnikov, A.N, Yang, S, Zhou, M.-M.
Deposit date:2013-10-07
Release date:2014-01-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
4N4F
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BU of 4n4f by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with di-Acetylated Histone 4 Peptide (H412acK16ac).
Descriptor: CREB-binding protein, Histone 4 Peptide, ZINC ION
Authors:Plotnikov, A.N, Zhou, J, Zhou, M.-M.
Deposit date:2013-10-08
Release date:2014-02-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014
5ULA
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BU of 5ula by Molmil
Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402
Descriptor: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, j, Zhou, M.-M.
Deposit date:2017-01-24
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4NUC
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BU of 4nuc by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS435 inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUE
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BU of 4nue by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4NUD
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BU of 4nud by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, Bromodomain-containing protein 4
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2013-12-03
Release date:2014-04-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56, 2013
4QB3
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BU of 4qb3 by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with Olinone
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide
Authors:Plotnikov, A.N, Joshua, J, Zhou, M.-M.
Deposit date:2014-05-06
Release date:2015-04-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (0.94 Å)
Cite:Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression.
Chem.Biol., 21, 2014
1NUN
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BU of 1nun by Molmil
Crystal Structure Analysis of the FGF10-FGFR2b Complex
Descriptor: Fibroblast growth factor-10, POLYETHYLENE GLYCOL (N=34), SULFATE ION, ...
Authors:Yeh, B.K, Igarashi, M, Eliseenkova, A.V, Plotnikov, A.N, Sher, I, Ron, D, Aaronson, S.A, Mohammadi, M.
Deposit date:2003-01-31
Release date:2003-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.
Proc.Natl.Acad.Sci.USA, 100, 2003
4JS8
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BU of 4js8 by Molmil
Crystal structure of TTK kinase domain with an inhibitor: 401348
Descriptor: 4-(cyclohexylmethoxy)-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-2H-indazole, DI(HYDROXYETHYL)ETHER, Dual specificity protein kinase TTK, ...
Authors:Qiu, W, Plotnikov, A.N, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y.
Deposit date:2013-03-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of TTK kinase domain with an inhibitor: 401348
To be Published
6DK3
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BU of 6dk3 by Molmil
HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2
Descriptor: Serine hydroxymethyltransferase, mitochondrial, UNKNOWN ATOM OR ION
Authors:Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2018-05-28
Release date:2018-06-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2
to be published
3HNA
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BU of 3hna by Molmil
Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Mono-Methylated H3K9 Peptide, ...
Authors:Min, J, Wu, H, Loppnau, P, Wleigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2009-05-30
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural biology of human H3K9 methyltransferases
Plos One, 5, 2010
3IHX
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BU of 3ihx by Molmil
Methyltransferase domain of human PR domain-containing protein 10
Descriptor: PR domain zinc finger protein 10
Authors:Amaya, M.F, Dombrovski, L, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2009-07-31
Release date:2009-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Methyltransferase domain of human PR domain-containing protein 10
To be Published
4X3S
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BU of 4x3s by Molmil
Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170me3 Peptide
Descriptor: CITRIC ACID, Chromobox protein homolog 7, FE (III) ION, ...
Authors:Ren, C, Plotnikov, A.N, Zhou, M.M.
Deposit date:2014-12-01
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.
Chem.Biol., 22, 2015
4F3I
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BU of 4f3i by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
Authors:Joshua, J, Zhou, M.-M, Plotnikov, A.N.
Deposit date:2012-05-09
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Down-regulation of NF-{kappa}B Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition.
J.Biol.Chem., 287, 2012
3ORH
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BU of 3orh by Molmil
Human guanidinoacetate N-methyltransferase with SAH
Descriptor: Guanidinoacetate N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Dong, A, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2010-09-07
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The crystal structure of human guanidinoacetate N-methyltransferase with SAH
TO BE PUBLISHED
1FQ9
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BU of 1fq9 by Molmil
CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 2, ...
Authors:Schlessinger, J, Plotnikov, A.N, Ibrahimi, O.A, Eliseenkova, A.V, Yeh, B.K, Yayon, A, Linhardt, R.J, Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
1IIL
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BU of 1iil by Molmil
CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2
Authors:Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M.
Deposit date:2001-04-23
Release date:2001-05-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1IJT
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BU of 1ijt by Molmil
Crystal Structure of Fibroblast Growth Factor 4 (FGF4)
Descriptor: SULFATE ION, fibroblast growth factor 4
Authors:Bellosta, P, Plotnikov, A.N, Eliseenkova, A.V, Basilico, C, Mohammadi, M.
Deposit date:2001-04-29
Release date:2001-08-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.
Mol.Cell.Biol., 21, 2001
1II4
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BU of 1ii4 by Molmil
CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
Descriptor: FIBROBLAST GROWTH FACTOR RECEPTOR 2, HEPARIN-BINDING GROWTH FACTOR 2
Authors:Ibrahimi, O.A, Eliseenkova, A.V, Plotnikov, A.N, Ornitz, D.M, Mohammadi, M.
Deposit date:2001-04-20
Release date:2001-05-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proc.Natl.Acad.Sci.USA, 98, 2001
1ZD1
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BU of 1zd1 by Molmil
Human Sulfortransferase SULT4A1
Descriptor: GLYCEROL, Sulfotransferase 4A1
Authors:Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
1ZRH
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BU of 1zrh by Molmil
Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
Descriptor: ADENOSINE-3'-5'-DIPHOSPHATE, Heparan sulfate glucosamine 3-O-sulfotransferase 1
Authors:Dong, A, Dombrovski, L, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2005-05-19
Release date:2005-06-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP
To be Published

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