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6ZQK
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BU of 6zqk by Molmil
HER2-binding scFv-Fab fusion 841
Descriptor: 1,2-ETHANEDIOL, 841 heavy chain, 841 light chain
Authors:Kast, F, Schwill, M, Stueber, J.C, Pfundstein, S, Nagy-Davidescu, G, Monne Rodriguez, J.M, Seehusen, F, Richter, C.P, Honegger, A, Hartmann, K.P, Weber, T.G, Kroener, F, Ernst, P, Piehler, J, Plueckthun, A.
Deposit date:2020-07-09
Release date:2021-06-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.
Nat Commun, 12, 2021
2NUB
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BU of 2nub by Molmil
Structure of Aquifex aeolicus Argonuate
Descriptor: Argonaute
Authors:Rashid, U.J, Paterok, D, Koglin, A, Gohlke, H, Piehler, J, Chen, J.C.-H.
Deposit date:2006-11-09
Release date:2007-02-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function.
J.Biol.Chem., 282, 2007
7Z3Q
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BU of 7z3q by Molmil
Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
Descriptor: Leptin, Leptin receptor
Authors:Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N.
Deposit date:2022-03-02
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.617 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
7Z3R
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BU of 7z3r by Molmil
Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
Authors:Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A.
Deposit date:2022-03-02
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.951 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
7Z3P
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BU of 7z3p by Molmil
Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution.
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ...
Authors:Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K.
Deposit date:2022-03-02
Release date:2023-03-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.943 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
7ZMZ
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BU of 7zmz by Molmil
Engineered Interleukin 2 bound to CD25 receptor
Descriptor: Interleukin-2, Interleukin-2 receptor subunit alpha
Authors:Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S.
Deposit date:2022-04-20
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Sci Immunol, 7, 2022
8G04
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BU of 8g04 by Molmil
Structure of signaling thrombopoietin-MPL receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ...
Authors:Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
Deposit date:2023-01-31
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
Cell(Cambridge,Mass.), 186, 2023
7P3Y
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BU of 7p3y by Molmil
Homology model of the full-length AP-3 complex in an intermediate open conformation
Descriptor: AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
Authors:Schubert, E, Raunser, S.
Deposit date:2021-07-09
Release date:2021-09-29
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi.
J.Biol.Chem., 297, 2021
7P3Z
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BU of 7p3z by Molmil
Homology model of the full-length AP-3 complex in a stretched open conformation
Descriptor: AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
Authors:Schubert, E, Raunser, S.
Deposit date:2021-07-09
Release date:2021-09-29
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (10.5 Å)
Cite:Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi.
J.Biol.Chem., 297, 2021
7P3X
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BU of 7p3x by Molmil
Homology model of the full-length AP-3 complex in a compact open conformation
Descriptor: AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
Authors:Schubert, E, Raunser, S.
Deposit date:2021-07-09
Release date:2021-09-29
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi.
J.Biol.Chem., 297, 2021
6E3K
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BU of 6e3k by Molmil
Interferon gamma signalling complex with IFNGR1 and IFNGR2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jude, K.M, Mendoza, J.L, Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6E3L
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BU of 6e3l by Molmil
Interferon gamma signalling complex with IFNGR1 and IFNGR2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ...
Authors:Jude, K.M, Mendoza, J.L, Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
5E4E
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BU of 5e4e by Molmil
Engineered Interleukin-13 bound to receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ...
Authors:Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C.
Deposit date:2015-10-05
Release date:2015-12-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.
Sci.Signal., 8, 2015
5UN6
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BU of 5un6 by Molmil
Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset
Descriptor: Designed Wnt agonist B12, Frizzled-8
Authors:Janda, C.Y, Garcia, K.C, Jude, K.M.
Deposit date:2017-01-30
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Nature, 545, 2017
5UN5
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BU of 5un5 by Molmil
Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1
Descriptor: Designed Wnt agonist B12, Frizzled-8
Authors:Janda, C.Y, Garcia, K.C.
Deposit date:2017-01-30
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Nature, 545, 2017
8AVE
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BU of 8ave by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)
Descriptor: Leptin, Leptin receptor
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (5.62 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVO
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BU of 8avo by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model).
Descriptor: Leptin, Leptin receptor
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (6.84 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8B7Q
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BU of 8b7q by Molmil
Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-09-30
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVC
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BU of 8avc by Molmil
Mouse leptin:LEP-R complex cryoEM structure (3:3 model)
Descriptor: Leptin, Leptin receptor, NICKEL (II) ION
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AV2
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BU of 8av2 by Molmil
Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ...
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVD
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BU of 8avd by Molmil
Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)
Descriptor: Leptin, Leptin receptor, NICKEL (II) ION
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (4.42 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVF
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BU of 8avf by Molmil
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model)
Descriptor: Leptin, Leptin receptor
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (6.45 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
8AVB
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BU of 8avb by Molmil
Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model).
Descriptor: Leptin, Leptin receptor
Authors:Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
Deposit date:2022-08-26
Release date:2023-04-05
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.43 Å)
Cite:Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
4Y5Y
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BU of 4y5y by Molmil
Diabody 330 complex with EpoR
Descriptor: Erythropoietin receptor, GLYCEROL, diabody 330 VH domain, ...
Authors:Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C.
Deposit date:2015-02-12
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
4Y5X
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BU of 4y5x by Molmil
Diabody 305 complex with EpoR
Descriptor: CITRATE ANION, DI(HYDROXYETHYL)ETHER, Erythropoietin receptor, ...
Authors:Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C.
Deposit date:2015-02-12
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015

 

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