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1BZQ
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BU of 1bzq by Molmil
COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A
Descriptor: PHOSPHATE ION, PROTEIN (ANTIBODY CAB-RN05), PROTEIN (RNASE A)
Authors:Decanniere, K, Desmyter, A, Gahroudhi, M, Lauwereys, M, Muyldermans, S, Wyns, L.
Deposit date:1998-11-03
Release date:1998-11-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.
Structure Fold.Des., 7, 1999
6FE4
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BU of 6fe4 by Molmil
Crystal structure of the complex between Shiga toxin Stx2 B subunit and neutralising Nb113
Descriptor: Nb113, Shiga-like toxin 2 subunit B
Authors:Bernedo, R, Muyldermans, S, Sterckx, Y.G.J.
Deposit date:2017-12-29
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment.
Toxins (Basel), 10, 2018
3G9A
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BU of 3g9a by Molmil
Green fluorescent protein bound to minimizer nanobody
Descriptor: Green fluorescent protein, Minimizer
Authors:Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U.
Deposit date:2009-02-13
Release date:2009-12-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.614 Å)
Cite:Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
3K1K
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BU of 3k1k by Molmil
Green fluorescent protein bound to enhancer nanobody
Descriptor: Enhancer, Green Fluorescent Protein
Authors:Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U.
Deposit date:2009-09-28
Release date:2009-12-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
4I0C
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BU of 4i0c by Molmil
The structure of the camelid antibody cAbHuL5 in complex with human lysozyme
Descriptor: CHLORIDE ION, GLYCEROL, Lysozyme C, ...
Authors:De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M.
Deposit date:2012-11-16
Release date:2013-10-09
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
1F2X
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BU of 1f2x by Molmil
STRUCTURE OF THE SINGLE-DOMAIN CAMELID ANTIBODY CAB-CA05
Descriptor: ANTIBODY HEAVY CHAIN
Authors:Decanniere, K, Muyldermans, S, Wyns, L.
Deposit date:2000-05-30
Release date:2000-06-08
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?
J.Mol.Biol., 300, 2000
1GHC
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BU of 1ghc by Molmil
HOMO-AND HETERONUCLEAR TWO-DIMENSIONAL NMR STUDIES OF THE GLOBULAR DOMAIN OF HISTONE H1: FULL ASSIGNMENT, TERTIARY STRUCTURE, AND COMPARISON WITH THE GLOBULAR DOMAIN OF HISTONE H5
Descriptor: GH1
Authors:Cerf, C, Lippens, G, Ramakrishnan, V, Muyldermans, S, Segers, A, Wyns, L, Wodak, S.J, Hallenga, K.
Deposit date:1994-05-16
Release date:1994-08-31
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: full assignment, tertiary structure, and comparison with the globular domain of histone H5.
Biochemistry, 33, 1994
3EAK
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BU of 3eak by Molmil
NbBCII10 humanized (FGLA mutant)
Descriptor: NbBCII10-FGLA, SULFATE ION
Authors:Vincke, C, Loris, R, Saerens, D, Martinez-Rodriguez, S, Muyldermans, S, Conrath, K.
Deposit date:2008-08-26
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
J.Biol.Chem., 2008
3EBA
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BU of 3eba by Molmil
CAbHul6 FGLW mutant (humanized) in complex with human lysozyme
Descriptor: CAbHul6, Lysozyme C, SULFATE ION
Authors:Loris, R, Vincke, C, Saerens, D, Martinez-Rodriguez, S, Muyldermans, S, Conrath, K.
Deposit date:2008-08-27
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
J.Biol.Chem., 284, 2009
3DWT
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BU of 3dwt by Molmil
Structure of CabBCII-10 nanobody
Descriptor: GLYCEROL, cAbBCII-10
Authors:Vincke, C, Loris, R, Muyldermans, S, Conrath, K.
Deposit date:2008-07-23
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
J.Biol.Chem., 2008
1KXT
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BU of 1kxt by Molmil
Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase
Descriptor: ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ...
Authors:Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXQ
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BU of 1kxq by Molmil
Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase
Descriptor: CALCIUM ION, CHLORIDE ION, alpha-amylase, ...
Authors:Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXV
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BU of 1kxv by Molmil
Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase
Descriptor: ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10
Authors:Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1XFP
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BU of 1xfp by Molmil
Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme
Descriptor: FORMIC ACID, Lysozyme C, heavy chain antibody
Authors:De Genst, E, Handelberg, F, Van Meirhaeghe, A, Vynck, S, Loris, R, Wyns, L, Muyldermans, S.
Deposit date:2004-09-15
Release date:2004-09-28
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody
J.Biol.Chem., 279, 2004
1G6V
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BU of 1g6v by Molmil
Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase
Descriptor: ANTIBODY HEAVY CHAIN, CARBONIC ANHYDRASE, ZINC ION
Authors:Desmyter, A, Decanniere, K, Muyldermans, S, Wyns, L.
Deposit date:2000-11-08
Release date:2000-11-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.
J.Biol.Chem., 276, 2001
1JTT
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BU of 1jtt by Molmil
Degenerate interfaces in antigen-antibody complexes
Descriptor: FORMIC ACID, Lysozyme, SODIUM ION, ...
Authors:Decanniere, K, Transue, T.R, Desmyter, A, Maes, D, Muyldermans, S, Wyns, L.
Deposit date:2001-08-22
Release date:2001-12-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
1JTO
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BU of 1jto by Molmil
Degenerate interfaces in antigen-antibody complexes
Descriptor: Lysozyme, Vh Single-Domain Antibody
Authors:Decanniere, K, Transue, T.R, Desmyter, A, Maes, D, Muyldermans, S, Wyns, L.
Deposit date:2001-08-21
Release date:2001-10-31
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
1JTP
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BU of 1jtp by Molmil
Degenerate interfaces in antigen-antibody complexes
Descriptor: FORMIC ACID, LYSOZYME C, SODIUM ION, ...
Authors:Decanniere, K, Transue, T.R, Desmyter, A, Maes, D, Muyldermans, S, Wyns, L.
Deposit date:2001-08-21
Release date:2001-12-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
1YC8
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BU of 1yc8 by Molmil
cAbAn33- Y37V/E44G/R45L triple mutant
Descriptor: anti-VSG immunoglobulin heavy chain variable domain cAbAn33
Authors:Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R.
Deposit date:2004-12-22
Release date:2005-06-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
1YC7
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BU of 1yc7 by Molmil
cAbAn33 VHH fragment against VSG
Descriptor: SULFATE ION, anti-VSG immunoglobulin heavy chain variable domain cAbAn33
Authors:Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R.
Deposit date:2004-12-22
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
5LHR
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BU of 5lhr by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22
Descriptor: Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
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BU of 5lhp by Molmil
The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHN
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BU of 5lhn by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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BU of 5lhq by Molmil
The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
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BU of 5lhs by Molmil
The ligand free catalytic domain of murine urokinase-type plasminogen activator
Descriptor: NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017

 

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