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1AIE
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BU of 1aie by Molmil
P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE
Descriptor: P53
Authors:Mittl, P.R.E, Chene, P, Gruetter, M.G.
Deposit date:1997-04-17
Release date:1997-06-16
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template.
Acta Crystallogr.,Sect.D, 54, 1998
8A19
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BU of 8a19 by Molmil
Structure of a leucinostatin derivative determined by host lattice display : L1E4V1 construct
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, ...
Authors:Mittl, P.R.E.
Deposit date:2022-06-01
Release date:2022-12-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.358 Å)
Cite:Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallogr D Struct Biol, 78, 2022
8A1A
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BU of 8a1a by Molmil
Structure of a leucinostatin derivative determined by host lattice display : L1F11V1 construct
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, ...
Authors:Mittl, P.R.E.
Deposit date:2022-06-01
Release date:2022-12-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallogr D Struct Biol, 78, 2022
1GES
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BU of 1ges by Molmil
ANATOMY OF AN ENGINEERED NAD-BINDING SITE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE
Authors:Mittl, P.R.E, Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Anatomy of an engineered NAD-binding site.
Protein Sci., 3, 1994
1GEU
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BU of 1geu by Molmil
ANATOMY OF AN ENGINEERED NAD-BINDING SITE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Mittl, P.R.E, Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anatomy of an engineered NAD-binding site.
Protein Sci., 3, 1994
1GET
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BU of 1get by Molmil
ANATOMY OF AN ENGINEERED NAD-BINDING SITE
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mittl, P.R.E, Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Anatomy of an engineered NAD-binding site.
Protein Sci., 3, 1994
2DKO
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BU of 2dko by Molmil
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Descriptor: Caspase-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Mittl, P.R.E, Ganesan, R, Jelakovic, S, Grutter, M.G.
Deposit date:2006-04-12
Release date:2006-07-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis
J.Mol.Biol., 359, 2006
5OD1
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BU of 5od1 by Molmil
Structure of the engineered metalloesterase MID1sc10 complexed with a phosphonate transition state analogue
Descriptor: GLYCEROL, MID1sc10, ZINC ION, ...
Authors:Mittl, P.R.E, Studer, S, Hansen, D.A, Hilvert, D.
Deposit date:2017-07-04
Release date:2018-12-12
Last modified:2020-04-22
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Evolution of a highly active and enantiospecific metalloenzyme from short peptides.
Science, 362, 2018
7BHE
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BU of 7bhe by Molmil
DARPin_D5/Her3 domain 4 complex, monoclinic crystals
Descriptor: ACETATE ION, DARPin_D5, GLYCEROL, ...
Authors:Mittl, P.R.E, Radom, F, Pluckthun, A.
Deposit date:2021-01-11
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5.
Acta Crystallogr.,Sect.F, 77, 2021
7BHF
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BU of 7bhf by Molmil
DARPin_D5/Her3 domain 4 complex, orthorhombic crystals
Descriptor: ACETATE ION, DARPin_D5, Isoform 4 of Receptor tyrosine-protein kinase erbB-3
Authors:Mittl, P.R.E, Radom, F, Pluckthun, A.
Deposit date:2021-01-11
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5.
Acta Crystallogr.,Sect.F, 77, 2021
8QBA
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BU of 8qba by Molmil
Sperm whale myoblogin mutant H64V V68A in complex with glycine ethyl ester
Descriptor: ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Tinzl, M, Mittl, P.R.E, Hilvert, D.
Deposit date:2023-08-24
Release date:2023-12-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
8QBC
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BU of 8qbc by Molmil
Reactive amide intermediate in sperm whale myoglobin mutant H64V V68A
Descriptor: ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Tinzl, M, Mittl, P.R.E, Hilvert, D.
Deposit date:2023-08-24
Release date:2023-12-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
7QNP
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BU of 7qnp by Molmil
Designed Armadillo repeat protein N(A4)M4C(AII) co-crystallized with hen egg white lysozyme
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Designed Armadillo Repeat Protein N(A4)M4C(AII), ...
Authors:Michel, E, Mittl, P.R.E, Plueckthun, A.
Deposit date:2021-12-21
Release date:2022-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.586 Å)
Cite:Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design.
Biochemistry, 62, 2023
6SA7
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BU of 6sa7 by Molmil
DARPin-Armadillo fusion C8long83
Descriptor: DARPin-Armadillo fusion C8long83
Authors:Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A.
Deposit date:2019-07-16
Release date:2019-11-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
6SA8
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BU of 6sa8 by Molmil
ring-like DARPin-Armadillo fusion H83_D01
Descriptor: 1,2-ETHANEDIOL, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG, ring-like DARPin-Armadillo fusion H83_D01
Authors:Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A.
Deposit date:2019-07-16
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
6SH9
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BU of 6sh9 by Molmil
EngBF DARPin Fusion 4b D12
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-alpha-N-acetylgalactosaminidase,DARPin 4b D12, ...
Authors:Ernst, P, Pluckthun, A, Mittl, P.R.E.
Deposit date:2019-08-06
Release date:2019-11-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
6SA6
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BU of 6sa6 by Molmil
DARPin-Armadillo fusion A5
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DARPin-Armadillo fusion A5
Authors:Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Pluckthun, A.
Deposit date:2019-07-16
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
6QEV
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BU of 6qev by Molmil
EngBF DARPin Fusion 4b B6
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (II) ION, PEGA domain-containing protein,PEGA domain-containing protein,EngBF DARPin fusion B6 complex, ...
Authors:Ernst, P, Pluckthun, A, Mittl, P.R.E.
Deposit date:2019-01-08
Release date:2019-11-06
Last modified:2020-04-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
6QFK
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BU of 6qfk by Molmil
EngBF DARPin Fusion 4b G10
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Ernst, P, Pluckthun, A, Mittl, P.R.E.
Deposit date:2019-01-10
Release date:2019-11-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
6QEP
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BU of 6qep by Molmil
EngBF DARPin Fusion 4b H14
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ...
Authors:Ernst, P, Pluckthun, A, Mittl, P.R.E.
Deposit date:2019-01-08
Release date:2019-11-06
Last modified:2020-04-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
6QFO
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BU of 6qfo by Molmil
EngBF DARPin Fusion 9b 3G124
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ...
Authors:Ernst, P, Pluckthun, A, Mittl, P.R.E.
Deposit date:2019-01-10
Release date:2019-11-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
2CJX
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BU of 2cjx by Molmil
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Descriptor: CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G.
Deposit date:2006-04-09
Release date:2006-06-27
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
2CJY
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BU of 2cjy by Molmil
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Descriptor: CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G.
Deposit date:2006-04-09
Release date:2006-06-27
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
5OD9
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BU of 5od9 by Molmil
Structure of the engineered metalloesterase MID1sc9
Descriptor: (2~{S})-2-phenylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Studer, S, Mittl, P.R.E, Hilvert, D.
Deposit date:2017-07-05
Release date:2018-12-12
Last modified:2020-04-22
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Evolution of a highly active and enantiospecific metalloenzyme from short peptides.
Science, 362, 2018
4BS0
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BU of 4bs0 by Molmil
Crystal Structure of Kemp Eliminase HG3.17 E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole
Descriptor: 6-NITROBENZOTRIAZOLE, KEMP ELIMINASE HG3.17, SULFATE ION
Authors:Blomberg, R, Kries, H, Pinkas, D.M, Mittl, P.R.E, Gruetter, M.G, Privett, H.K, Mayo, S, Hilvert, D.
Deposit date:2013-06-06
Release date:2013-10-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Precision is Essential for Efficient Catalysis in an Evolved Kemp Eliminase
Nature, 503, 2013

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