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6PTL
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BU of 6ptl by Molmil
Structure of the self-association domain of the chromatin looping factor LDB1
Descriptor: LIM domain-binding protein 1
Authors:Macindoe, I, Silva, A, Guss, J.M, Mackay, J.P, Matthews, J.M.
Deposit date:2019-07-16
Release date:2020-07-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the self-association domain of the chromatin looping factor LDB1
To Be Published
3MMK
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BU of 3mmk by Molmil
The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification
Descriptor: CHLORIDE ION, Fusion of LIM/homeobox protein Lhx4, linker, ...
Authors:Gadd, M.S, Langley, D.B, Guss, J.M, Matthews, J.M.
Deposit date:2010-04-20
Release date:2011-07-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.157 Å)
Cite:The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification.
J.Biol.Chem., 2011
4MJ3
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BU of 4mj3 by Molmil
Haloalkane dehalogenase DmrA from Mycobacterium rhodesiae JS60
Descriptor: CHLORIDE ION, Haloalkane dehalogenase, POTASSIUM ION
Authors:Fung, H, Gadd, M.S, Guss, J.M, Matthews, J.M.
Deposit date:2013-09-03
Release date:2015-02-25
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes.
Mol.Microbiol., 97, 2015
3VD6
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BU of 3vd6 by Molmil
Both Zn Fingers of GATA1 Bound to Palindromic DNA Recognition Site, P21 Crystal Form
Descriptor: ACETATE ION, DNA (5'-D(*AP*AP*GP*AP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*TP*C)-3'), ...
Authors:Jacques, D.A, Ripin, N, Wilkinson-White, L.E, Guss, J.M, Matthews, J.M.
Deposit date:2012-01-04
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA.
Protein Sci., 24, 2015
3VEK
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BU of 3vek by Molmil
Both Zn Fingers of GATA1 Bound to Palindromic DNA Recognition Site, P1 Crystal Form
Descriptor: DNA (5'-D(*AP*AP*GP*AP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*TP*C)-3'), Erythroid transcription factor, ...
Authors:Jacques, D.A, Ripin, N, Wilkinson-White, L.E, Guss, J.M, Matthews, J.M.
Deposit date:2012-01-09
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA.
Protein Sci., 24, 2015
6CME
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BU of 6cme by Molmil
Structure of wild-type ISL2-LID in complex with LHX4-LIM1+2
Descriptor: LIM/homeobox protein Lhx4,Insulin gene enhancer protein ISL-2, ZINC ION
Authors:Stokes, P.H, Silva, A, Guss, J.M, Matthews, J.M.
Deposit date:2018-03-04
Release date:2019-04-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Mutation in a flexible linker modulates binding affinity for modular complexes.
Proteins, 87, 2019
4JCJ
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BU of 4jcj by Molmil
Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain
Descriptor: Insulin gene enhancer protein ISL-1,LIM domain-binding protein 1, ZINC ION
Authors:Gadd, M.S, Jacques, D.A, Guss, J.M, Matthews, J.M.
Deposit date:2013-02-21
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.
J.Biol.Chem., 288, 2013
2RGT
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BU of 2rgt by Molmil
Crystal Structure of Lhx3 LIM domains 1 and 2 with the binding domain of Isl1
Descriptor: Fusion of LIM/homeobox protein Lhx3, linker, Insulin gene enhancer protein ISL-1, ...
Authors:Bhati, M, Lee, M, Guss, J.M, Matthews, J.M.
Deposit date:2007-10-05
Release date:2008-08-12
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.
Embo J., 27, 2008
2LXD
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BU of 2lxd by Molmil
Backbone 1H, 13C, and 15N Chemical Shift Assignments for LMO2(LIM2)-Ldb1(LID)
Descriptor: Rhombotin-2,LIM domain-binding protein 1, ZINC ION
Authors:Dastmalchi, S, Wilkinson-White, L, Kwan, A.H, Gamsjaeger, R, Mackay, J.P, Matthews, J.M.
Deposit date:2012-08-20
Release date:2012-09-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex.
Protein Sci., 21, 2012
2JTN
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BU of 2jtn by Molmil
NMR Solution Structure of a ldb1-LID:Lhx3-LIM complex
Descriptor: LIM domain-binding protein 1, LIM/homeobox protein Lhx3, ZINC ION
Authors:Lee, C, Nancarrow, A.L, Mackay, J.P, Matthews, J.M.
Deposit date:2007-08-03
Release date:2008-06-17
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
Embo J., 27, 2008
1RUT
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BU of 1rut by Molmil
Complex of LMO4 LIM domains 1 and 2 with the ldb1 LID domain
Descriptor: Fusion protein of Lmo4 protein and LIM domain-binding protein 1, ZINC ION
Authors:Deane, J.E, Ryan, D.P, Maher, M.J, Kwan, A.H.Y, Bacca, M, Mackay, J.P, Guss, J.M, Visvader, J.E, Matthews, J.M.
Deposit date:2003-12-11
Release date:2004-10-12
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex
Embo J., 23, 2004
2DFY
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BU of 2dfy by Molmil
Crystal structure of a cyclized protein fusion of LMO4 LIM domains 1 and 2 with the LIM interacting domain of LDB1
Descriptor: GLYCEROL, ZINC ION, fusion protein of LIM domain transcription factor LMO4 and LIM domain-binding protein 1
Authors:Jeffries, C.M.J, Graham, S.C, Collyer, C.A, Guss, J.M, Matthews, J.M.
Deposit date:2006-03-06
Release date:2006-10-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stabilization of a binary protein complex by intein-mediated cyclization
Protein Sci., 15, 2006
2MF8
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BU of 2mf8 by Molmil
HADDOCK model of MyT1 F4F5 - DNA complex
Descriptor: DNA (5'-D(*AP*CP*CP*GP*AP*AP*AP*GP*TP*TP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*AP*AP*CP*TP*TP*TP*CP*GP*GP*T)-3'), Myelin transcription factor 1, ...
Authors:Gamsjaeger, R, O'Connell, M.R, Cubeddu, L, Shepherd, N.E, Lowry, J.A, Kwan, A.H, Vandevenne, M, Swanton, M.K, Matthews, J.M, Mackay, J.P.
Deposit date:2013-10-08
Release date:2013-11-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.
J.Biol.Chem., 288, 2013
2MBV
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BU of 2mbv by Molmil
LMO4-LIM2 in complex with DEAF1 (404-418)
Descriptor: Fusion protein of LIM domain transcription factor LMO4 (77-147) and DEAF1 (404-418), ZINC ION
Authors:Joseph, S, Matthews, J.M, Kwan, A.H.-Y, Mackay, J.P, Cubeddu, L, Foo, P.
Deposit date:2013-08-06
Release date:2014-08-20
Method:SOLUTION NMR
Cite:Structural characterisation of LIM-only protein 4 (LMO4) in complex with Deformed Epidermal Autoregulatory Factor-1 (DEAF1)
To be Published
2JYD
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BU of 2jyd by Molmil
Structure of the fifth zinc finger of Myelin Transcription Factor 1
Descriptor: F5 domain of Myelin transcription factor 1, ZINC ION
Authors:Gamsjaeger, R, Swanton, M.K, Kobus, F.J, Lehtomaki, E, Lowry, J.A, Kwan, A.H, Matthews, J.M, Mackay, J.P.
Deposit date:2007-12-12
Release date:2008-01-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.
J.Biol.Chem., 283, 2008
2JX1
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BU of 2jx1 by Molmil
Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA
Descriptor: DNA (5'-D(*DAP*DCP*DCP*DGP*DAP*DAP*DAP*DGP*DTP*DTP*DCP*DAP*DC)-3'), DNA (5'-D(*DGP*DTP*DGP*DAP*DAP*DCP*DTP*DTP*DTP*DCP*DGP*DGP*DT)-3'), Myelin transcription factor 1
Authors:Gamsjaeger, R, Swanton, M.K, Kobus, F.J, Lehtomaki, E, Lowry, J.A, Kwan, A.H, Matthews, J.M, Mackay, J.P.
Deposit date:2007-11-01
Release date:2007-12-11
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA
To be Published
2KAE
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BU of 2kae by Molmil
data-driven model of MED1:DNA complex
Descriptor: 5'-D(*DCP*DGP*DGP*DAP*DAP*DAP*DAP*DGP*DTP*DAP*DTP*DAP*DCP*DTP*DTP*DTP*DTP*DCP*DCP*DG)-3', GATA-type transcription factor, ZINC ION
Authors:Lowry, J.A, Gamsjaeger, R, Thong, S, Hung, W, Kwan, A.H, Broitman-Maduro, G, Matthews, J.M, Maduro, M, Mackay, J.P.
Deposit date:2008-11-04
Release date:2009-01-06
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural Analysis of MED-1 Reveals Unexpected Diversity in the Mechanism of DNA Recognition by GATA-type Zinc Finger Domains.
J.Biol.Chem., 284, 2009
2L6Z
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BU of 2l6z by Molmil
haddock model of GATA1NF:Lmo2LIM2-Ldb1LID with FOG
Descriptor: Erythroid transcription factor, LIM domain only 2, linker, ...
Authors:Wilkinson-White, L, Gamsjaeger, R, Dastmalchi, S, Wienert, B, Stokes, P.H, Crossley, M, Mackay, J.P, Matthews, J.M.
Deposit date:2010-12-01
Release date:2011-08-31
Last modified:2011-09-28
Method:SOLUTION NMR
Cite:Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
Proc.Natl.Acad.Sci.USA, 108, 2011
2L4Z
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BU of 2l4z by Molmil
NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82)
Descriptor: DNA endonuclease RBBP8,LIM domain transcription factor LMO4, ZINC ION
Authors:Liew, C, Stokes, P.H, Kwan, A.H, Matthews, J.M.
Deposit date:2010-10-22
Release date:2011-10-26
Last modified:2023-07-26
Method:SOLUTION NMR
Cite:Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8.
J.Mol.Biol., 425, 2013
2L6Y
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BU of 2l6y by Molmil
haddock model of GATA1NF:Lmo2LIM2-Ldb1LID
Descriptor: Erythroid transcription factor, LIM domain only 2, linker, ...
Authors:Wilkinson-White, L, Gamsjaeger, R, Dastmalchi, S, Wienert, B, Stokes, P.H, Crossley, M, Mackay, J.P, Matthews, J.M.
Deposit date:2010-12-01
Release date:2011-08-31
Last modified:2011-09-28
Method:SOLUTION NMR
Cite:Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
Proc.Natl.Acad.Sci.USA, 108, 2011
1U85
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BU of 1u85 by Molmil
ARG326-TRP mutant of the third zinc finger of BKLF
Descriptor: Kruppel-like factor 3, ZINC ION
Authors:Cram, E.D, Mackay, J.P, Matthews, J.M.
Deposit date:2004-08-05
Release date:2005-08-23
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Solution structures of tryptophan-containing CCHH zinc finger mutants
To be Published
1U86
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BU of 1u86 by Molmil
321-TW-322 insertion mutant of the third zinc finger of BKLF
Descriptor: Kruppel-like factor 3, ZINC ION
Authors:Cram, E.D, Mackay, J.P, Matthews, J.M.
Deposit date:2004-08-05
Release date:2005-08-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of tryptophan-containing CCHH zinc finger mutants
To be Published
1WO3
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BU of 1wo3 by Molmil
Solution structure of Minimal Mutant 1 (MM1): Multiple alanine mutant of non-native CHANCE domain
Descriptor: CREB Binding Protein, ZINC ION
Authors:Sharpe, B.K, Liew, C.K, Wilce, J.A, Crossley, M, Matthews, J.M, Mackay, J.P.
Deposit date:2004-08-12
Release date:2005-03-08
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting
Structure, 13, 2005
1WO6
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BU of 1wo6 by Molmil
Solution structure of Designed Functional Finger 5 (DFF5): Designed mutant based on non-native CHANCE domain
Descriptor: CREB Binding Protein, ZINC ION
Authors:Sharpe, B.K, Liew, C.K, Wilce, J.A, Crossley, M, Matthews, J.M, Mackay, J.P.
Deposit date:2004-08-12
Release date:2005-03-08
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting
Structure, 13, 2005
1WO4
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BU of 1wo4 by Molmil
Solution structure of Minimal Mutant 2 (MM2): Multiple alanine mutant of non-native CHANCE domain
Descriptor: CREB Binding Protein, ZINC ION
Authors:Sharpe, B.K, Liew, C.K, Wilce, J.A, Crossley, M, Matthews, J.M, Mackay, J.P.
Deposit date:2004-08-12
Release date:2005-03-08
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting
Structure, 13, 2005

 

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