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1SEM
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BU of 1sem by Molmil
STRUCTURAL DETERMINANTS OF PEPTIDE-BINDING ORIENTATION AND OF SEQUENCE SPECIFICITY IN SH3 DOMAINS
Descriptor: 10-RESIDUE PROLINE-RICH PEPTIDE FROM MSOS (ACE-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG), SEM-5
Authors:Lim, W.A, Richards, F.M, Fox, R.O.
Deposit date:1995-03-28
Release date:1995-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains.
Nature, 372, 1994
1LLI
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BU of 1lli by Molmil
THE CRYSTAL STRUCTURE OF A MUTANT PROTEIN WITH ALTERED BUT IMPROVED HYDROPHOBIC CORE PACKING
Descriptor: DNA (5'-D(*AP*AP*TP*AP*CP*CP*AP*CP*TP*GP*GP*CP*GP*GP*TP*GP*A P*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*TP*CP*AP*CP*CP*GP*CP*CP*AP*GP*TP*GP*G P*TP*AP*T)-3'), PROTEIN (LAMBDA REPRESSOR)
Authors:Lim, W.A, Hodel, A, Sauer, R.T, Richards, F.M.
Deposit date:1994-03-25
Release date:1994-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of a mutant protein with altered but improved hydrophobic core packing.
Proc.Natl.Acad.Sci.USA, 91, 1994
3SEM
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BU of 3sem by Molmil
SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Descriptor: SEX MUSCLE ABNORMAL PROTEIN 5, SH3 PEPTOID INHIBITOR
Authors:Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A.
Deposit date:1998-11-02
Release date:1999-01-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Science, 282, 1998
1B07
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BU of 1b07 by Molmil
CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Descriptor: PHENYLETHANE, PROTEIN (PROTO-ONCOGENE CRK (CRK)), PROTEIN (SH3 PEPTOID INHIBITOR)
Authors:Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A.
Deposit date:1998-11-17
Release date:1999-01-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Science, 282, 1998
3QBV
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BU of 3qbv by Molmil
Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin
Descriptor: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1
Authors:Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T.
Deposit date:2011-01-14
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Proc.Natl.Acad.Sci.USA, 109, 2012
3FZE
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BU of 3fze by Molmil
Structure of the 'minimal scaffold' (ms) domain of Ste5 that cocatalyzes Fus3 phosphorylation by Ste7
Descriptor: Protein STE5
Authors:Good, M.C, Tang, G, Singleton, J, Remenyi, A, Lim, W.A.
Deposit date:2009-01-25
Release date:2009-03-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.
Cell(Cambridge,Mass.), 136, 2009
2SEM
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BU of 2sem by Molmil
SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
Descriptor: PROTEIN (SEX MUSCLE ABNORMAL PROTEIN 5), PROTEIN (SH3 PEPTOID INHIBITOR)
Authors:Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A.
Deposit date:1998-11-02
Release date:1999-01-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Science, 282, 1998
2F9G
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BU of 2f9g by Molmil
Crystal structure of Fus3 phosphorylated on Tyr182
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3
Authors:Bhattacharyya, R.P, Remenyi, A, Good, M.C, Bashor, C.J, Falick, A.M, Lim, W.A.
Deposit date:2005-12-05
Release date:2006-11-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
Science, 311, 2006
2FA2
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BU of 2fa2 by Molmil
Crystal structure of Fus3 without a peptide from Ste5
Descriptor: Mitogen-activated protein kinase FUS3, THIOCYANATE ION
Authors:Bhattacharyya, R.P, Remenyi, A, Good, M.C, Bashor, C.J, Falick, A.M, Lim, W.A.
Deposit date:2005-12-06
Release date:2006-03-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
Science, 311, 2006
1QAU
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BU of 1qau by Molmil
UNEXPECTED MODES OF PDZ DOMAIN SCAFFOLDING REVEALED BY STRUCTURE OF NNOS-SYNTROPHIN COMPLEX
Descriptor: NEURONAL NITRIC OXIDE SYNTHASE (RESIDUES 1-130)
Authors:Hillier, B.J, Christopherson, K.S, Prehoda, K.E, Bredt, D.S, Lim, W.A.
Deposit date:1999-03-29
Release date:1999-05-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.
Science, 284, 1999
1QAV
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BU of 1qav by Molmil
Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of NNOS-Syntrophin Complex
Descriptor: ALPHA-1 SYNTROPHIN (RESIDUES 77-171), NEURONAL NITRIC OXIDE SYNTHASE (RESIDUES 1-130)
Authors:Hillier, B.J, Christopherson, K.S, Prehoda, K.E, Bredt, D.S, Lim, W.A.
Deposit date:1999-03-30
Release date:1999-05-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.
Science, 284, 1999
1EVH
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BU of 1evh by Molmil
EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE
Descriptor: PROTEIN (MENA EVH1 DOMAIN), Peptide ACTA
Authors:Prehoda, K.E, Lee, D.J, Lim, W.A.
Deposit date:1999-04-21
Release date:1999-05-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly.
Cell(Cambridge,Mass.), 97, 1999
4F2H
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BU of 4f2h by Molmil
Structure of the minimal Ste5 VWA domain subject to autoinhibition by the Ste5 PH domain
Descriptor: Protein STE5
Authors:Coyle, S.M, Zalatan, J.G, Lim, W.A.
Deposit date:2012-05-07
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.192 Å)
Cite:Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation.
Science, 337, 2012
1ZL8
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BU of 1zl8 by Molmil
NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins
Descriptor: LIN-7, Peripheral plasma membrane protein CASK
Authors:Petrosky, K.Y, Ou, H.D, Lohr, F, Dotsch, V, Lim, W.A.
Deposit date:2005-05-05
Release date:2005-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A General Model for Preferential Hetero-oligomerization of LIN-2/7 Domains: Mechanism Underlying Directed Assembly of Supramolecular Signaling Complexes
J.Biol.Chem., 280, 2005
2B9F
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BU of 2b9f by Molmil
Crystal structure of non-phosphorylated Fus3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B9J
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BU of 2b9j by Molmil
Crystal structure of Fus3 with a docking motif from Far1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cyclin-dependent kinase inhibitor FAR1, MAGNESIUM ION, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B9I
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BU of 2b9i by Molmil
Crystal structure of Fus3 with a docking motif from Msg5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B9H
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BU of 2b9h by Molmil
Crystal structure of Fus3 with a docking motif from Ste7
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
1KJW
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BU of 1kjw by Molmil
SH3-Guanylate Kinase Module from PSD-95
Descriptor: POSTSYNAPTIC DENSITY PROTEIN 95, SULFATE ION
Authors:McGee, A.W, Dakoji, S.R, Olsen, O, Bredt, D.S, Lim, W.A, Prehoda, K.E.
Deposit date:2001-12-05
Release date:2002-01-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the SH3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding Proteins
Mol.Cell, 8, 2001
1MKE
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BU of 1mke by Molmil
Structure of the N-WASP EVH1 Domain-WIP complex
Descriptor: Fusion protein consisting of Wiskott-Aldrich syndrome protein interacting protein (WIP), GSGSG linker, and Neural Wiskott-Aldrich syndrome protein (N-WASP)
Authors:Volkman, B.F, Prehoda, K.E, Scott, J.A, Peterson, F.C, Lim, W.A.
Deposit date:2002-08-29
Release date:2002-12-04
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structure of the N-WASP EVH1 Domain-WIP Complex. Insight into the Molecular Basis of Wiskott-Aldrich Syndrome.
Cell(Cambridge,Mass.), 111, 2002
2IFS
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BU of 2ifs by Molmil
Structure of the N-WASP EVH1 domain in complex with an extended WIP peptide
Descriptor: Wiskott-Aldrich Syndrome Protein interacting protein and Neural Wiskott-Aldrich syndrome protein chimera
Authors:Volkman, B.F, Peterson, F.C, Deng, Q.
Deposit date:2006-09-21
Release date:2007-01-16
Last modified:2020-09-02
Method:SOLUTION NMR
Cite:Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.
J.Biol.Chem., 282, 2007
3JV3
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BU of 3jv3 by Molmil
Structure of SH3E-DH unit of murine intersectin-1L
Descriptor: Intersectin-1
Authors:Ahmad, K.F.
Deposit date:2009-09-15
Release date:2010-07-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin.
Plos One, 5, 2010
2F49
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BU of 2f49 by Molmil
Crystal structure of Fus3 in complex with a Ste5 peptide
Descriptor: MAGNESIUM ION, Mitogen-activated protein kinase FUS3, STE5 peptide, ...
Authors:Remenyi, A.
Deposit date:2005-11-22
Release date:2006-03-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
Science, 311, 2006
2XKX
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BU of 2xkx by Molmil
Single particle analysis of PSD-95 in negative stain
Descriptor: DISKS LARGE HOMOLOG 4
Authors:Fomina, S, Howard, T.D, Sleator, O.K, Golovanova, M, O'Ryan, L, Leyland, M.L, Grossmann, J.G, Collins, R.F, Prince, S.M.
Deposit date:2010-07-15
Release date:2011-07-20
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (22.9 Å), SOLUTION SCATTERING
Cite:Self-Directed Assembly and Clustering of the Cytoplasmic Domains of Inwardly Rectifying Kir2.1 Potassium Channels on Association with Psd-95
Biochim.Biophys.Acta, 1808, 2011

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