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2YIM
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BU of 2yim by Molmil
The enolisation chemistry of a thioester-dependent racemase: the 1.4 A crystal structure of a complex with a planar reaction intermediate analogue
Descriptor: 2-METHYLACETOACETYL COA, GLYCEROL, PHOSPHATE ION, ...
Authors:Sharma, S, Bhaumik, P, Venkatesan, R, Hiltunen, J.K, Conzelmann, E, Juffer, A.H, Wierenga, R.K.
Deposit date:2011-05-16
Release date:2012-03-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:The Enolization Chemistry of a Thioester-Dependent Racemase: The 1.4 A Crystal Structure of a Reaction Intermediate Complex Characterized by Detailed Qm/Mm Calculations.
J Phys Chem B, 116, 2012
5MGB
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BU of 5mgb by Molmil
Crystal Structure of Rat Peroxisomal Multifunctional enzyme Type-1 (RPMFE1) Complexed with Acetoacetyl-CoA and NAD
Descriptor: ACETOACETYL-COENZYME A, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kasaragod, P, Kiema, T.-R, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2016-11-21
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase part.
FEBS Open Bio, 7, 2017
1DCI
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BU of 1dci by Molmil
DIENOYL-COA ISOMERASE
Descriptor: 1,2-ETHANEDIOL, DIENOYL-COA ISOMERASE, MAGNESIUM ION, ...
Authors:Modis, Y, Filppula, S.A, Novikov, D, Norledge, B, Hiltunen, J.K, Wierenga, R.K.
Deposit date:1998-02-13
Release date:1999-03-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.
Structure, 6, 1998
1X74
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BU of 1x74 by Molmil
Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis- mutational and structural characterization of the fold and active site
Descriptor: 2-methylacyl-CoA racemase, GLYCEROL, PHOSPHATE ION
Authors:Kalle, S, Bhaumik, P, Schmitz, W, Kotti, T.J, Conzelmann, E, Wierenga, R.K, Hiltunen, J.K.
Deposit date:2004-08-13
Release date:2005-01-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:{alpha}-Methylacyl-CoA Racemase from Mycobacterium tuberculosis: MUTATIONAL AND STRUCTURAL CHARACTERIZATION OF THE ACTIVE SITE AND THE FOLD
J.Biol.Chem., 280, 2005
1ZCJ
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BU of 1zcj by Molmil
Crystal structure of 3-hydroxyacyl-CoA dehydrogenase
Descriptor: Peroxisomal bifunctional enzyme
Authors:Taskinen, J.P, Kiema, T.R, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2005-04-12
Release date:2006-01-10
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Studies of MFE-1: the 1.9A Crystal Structure of the Dehydrogenase Part of Rat Peroxisomal MFE-1
J.Mol.Biol., 355, 2006
2X58
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BU of 2x58 by Molmil
The crystal structure of MFE1 liganded with CoA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, COENZYME A, GLYCEROL, ...
Authors:Kasaragod, P, Venkatesan, R, Kiema, T.R, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2010-02-05
Release date:2010-05-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of Liganded Rat Peroxisomal Multifunctional Enzyme Type 1: A Flexible Molecule with Two Interconnected Active Sites
J.Biol.Chem., 285, 2010
1K39
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BU of 1k39 by Molmil
The structure of yeast delta3-delta2-enoyl-COA isomerase complexed with octanoyl-COA
Descriptor: OCTANOYL-COENZYME A, PHOSPHATE ION, d3,d2-enoyl CoA isomerase ECI1
Authors:Mursula, A.M, Geerlof, A, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2001-10-02
Release date:2003-08-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:

1N9G
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BU of 1n9g by Molmil
Mitochondrial 2-enoyl thioester reductase Etr1p/Etr2p heterodimer from Candida tropicalis
Descriptor: 2,4-dienoyl-CoA reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Torkko, J.M, Koivuranta, K.T, Kastaniotis, A.J, Airenne, T.T, Glumoff, T, Ilves, M, Hartig, A, Gurvitz, A, Hiltunen, J.K.
Deposit date:2002-11-25
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers.
J.Biol.Chem., 278, 2003
3OML
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BU of 3oml by Molmil
Structure of full-length peroxisomal multifunctional enzyme type 2 from Drosophila melanogaster
Descriptor: Peroxisomal Multifunctional Enzyme Type 2, CG3415
Authors:Haataja, T.J.K, Koski, M.K, Glumoff, T, Hiltunen, J.K.
Deposit date:2010-08-27
Release date:2011-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics.
Biochem.J., 435, 2011
4CQM
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BU of 4cqm by Molmil
Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CARBONYL REDUCTASE FAMILY MEMBER 4, ...
Authors:Venkatesan, R, SahTeli, S.K, Awoniyi, L.O, Jiang, G, Prus, P, Kastoniotis, A.J, Hiltunen, J.K, Wierenga, R.K, Chen, Z.
Deposit date:2014-02-19
Release date:2014-09-10
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (2.339 Å)
Cite:Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
Nat.Commun., 5, 2014
4CQL
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BU of 4cql by Molmil
Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD
Descriptor: CARBONYL REDUCTASE FAMILY MEMBER 4, ESTRADIOL 17-BETA-DEHYDROGENASE 8, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Venkatesan, R, Sah-Teli, S.K, Awoniyi, L.O, Jiang, G, Prus, P, Kastaniotis, A.J, Hiltunen, J.K, Wierenga, R.K, Chen, Z.
Deposit date:2014-02-19
Release date:2014-09-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Insights Into Mitochondrial Fatty Acid Synthesis from the Structure of Heterotetrameric 3-Ketoacyl-Acp Reductase/3R-Hydroxyacyl-Coa Dehydrogenase.
Nat.Commun., 5, 2014
1HNU
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BU of 1hnu by Molmil
CRYSTAL STRUCTURE OF PEROXISOMAL DELTA3-DELTA2-ENOYL-COA ISOMERASE FROM SACCHAROMYCES CEREVISIAE
Descriptor: 1,2-ETHANEDIOL, D3,D2-ENOYL COA ISOMERASE ECI1, PERRHENATE
Authors:Mursula, A.M, van Aalten, D.M.F, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2000-12-08
Release date:2001-06-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase.
J.Mol.Biol., 309, 2001
1HNO
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BU of 1hno by Molmil
CRYSTAL STRUCTURE OF PEROXISOMAL DELTA3-DELTA2-ENOYL-COA ISOMERASE FROM SACCHAROMYCES CEREVISIAE
Descriptor: 1,2-ETHANEDIOL, D3,D2-ENOYL COA ISOMERASE ECI1
Authors:Mursula, A.M, van Aalten, D.M.F, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2000-12-08
Release date:2001-06-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase.
J.Mol.Biol., 309, 2001
3ZW9
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BU of 3zw9 by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH (2S,3S)-3-HYDROXY-2-METHYLBUTANOYL-COA
Descriptor: (2S,3S)-3-HYDROXY-2-METHYLBUTANOYL-COA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PEROXISOMAL BIFUNCTIONAL ENZYME, ...
Authors:Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2011-07-28
Release date:2012-08-08
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa.
FEBS J., 280, 2013
3ZW8
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BU of 3zw8 by Molmil
Crystal Structure Of Rat Peroxisomal Multifunctional Enzyme Type 1 (rpMFE1) In Apo Form
Descriptor: GLYCEROL, PEROXISOMAL BIFUNCTIONAL ENZYME, SULFATE ION
Authors:Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2011-07-28
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa.
FEBS J., 280, 2013
3ZWB
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BU of 3zwb by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 2TRANS-HEXENOYL-COA
Descriptor: (2E)-Hexenoyl-CoA, GLYCEROL, PEROXISOMAL BIFUNCTIONAL ENZYME, ...
Authors:Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2011-07-28
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa.
FEBS J., 280, 2013
3ZWC
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BU of 3zwc by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 3S-HYDROXY-DECANOYL-COA
Descriptor: (S)-3-HYDROXYDECANOYL-COA, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2011-07-28
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa.
FEBS J., 280, 2013
3ZWA
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BU of 3zwa by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 3S-HYDROXY-HEXANOYL-COA
Descriptor: (S)-3-Hydroxyhexanoyl-CoA, GLYCEROL, PEROXISOMAL BIFUNCTIONAL ENZYME, ...
Authors:Kasaragod, P, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2011-07-28
Release date:2012-08-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:The Isomerase and Hydratase Reaction Mechanism of the Crotonase Active Site of the Multifunctional Enzyme (Type-1), as Deduced from Structures of Complexes with 3S-Hydroxy- Acyl-Coa.
FEBS J., 280, 2013
5OMO
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BU of 5omo by Molmil
CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH WITH 3S-HYDROXY-DECANOYL-COA AND 3-KETO-DECANOYL-COA
Descriptor: (S)-3-HYDROXYDECANOYL-COA, 3-KETO-DECANOYL-COA, GLYCEROL, ...
Authors:Kasaragod, P, Kiema, T.-R, Schmitz, W, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2017-08-01
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 1 (RPMFE1) COMPLEXED WITH 3S-HYDROXY-DECANOYL-COA AND 3- KETO-DECANOYL-COA
Not Published
1PJH
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BU of 1pjh by Molmil
Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily
Descriptor: GLYCEROL, SULFATE ION, enoyl-CoA isomerase; Eci1p
Authors:Mursula, A.M, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2003-06-03
Release date:2004-01-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural studies on delta(3)-delta(2)-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily.
Febs Lett., 557, 2004
1PN4
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BU of 1pn4 by Molmil
Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.
Descriptor: 1,2-ETHANEDIOL, 3R-HYDROXYDECANOYL-COENZYME A, Peroxisomal hydratase-dehydrogenase-epimerase
Authors:Koski, M.K, Haapalainen, A.M, Hiltunen, J.K, Glumoff, T.
Deposit date:2003-06-12
Release date:2004-04-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A Two-domain Structure of One Subunit Explains Unique Features of Eukaryotic Hydratase 2.
J.Biol.Chem., 279, 2004
1PN2
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BU of 1pn2 by Molmil
Crystal structure analysis of the selenomethionine labelled 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2
Descriptor: 1,2-ETHANEDIOL, Peroxisomal hydratase-dehydrogenase-epimerase
Authors:Koski, M.K, Haapalainen, A.M, Hiltunen, J.K, Glumoff, T.
Deposit date:2003-06-12
Release date:2004-04-13
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Two-domain Structure of One Subunit Explains Unique Features of Eukaryotic Hydratase 2.
J.Biol.Chem., 279, 2004
1S9C
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BU of 1s9c by Molmil
Crystal structure analysis of the 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2
Descriptor: Peroxisomal multifunctional enzyme type 2
Authors:Koski, M.K, Haapalainen, A.M, Hiltunen, J.K, Glumoff, T.
Deposit date:2004-02-04
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2.
J.Mol.Biol., 345, 2005
1SG4
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BU of 1sg4 by Molmil
Crystal structure of human mitochondrial delta3-delta2-enoyl-CoA isomerase
Descriptor: 3,2-trans-enoyl-CoA isomerase, mitochondrial, OCTANOYL-COENZYME A
Authors:Partanen, S.T, Novikov, D.K, Popov, A.N, Mursula, A.M, Hiltunen, J.K, Wierenga, R.K.
Deposit date:2004-02-23
Release date:2005-01-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.
J.Mol.Biol., 342, 2004
2ET6
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BU of 2et6 by Molmil
(3R)-Hydroxyacyl-CoA Dehydrogenase Domain of Candida tropicalis Peroxisomal Multifunctional Enzyme Type 2
Descriptor: (3R)-hydroxyacyl-CoA dehydrogenase
Authors:Ylianttila, M.S, Hiltunen, J.K, Glumoff, T.
Deposit date:2005-10-27
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal Structure of Yeast Peroxisomal Multifunctional Enzyme: Structural Basis for Substrate Specificity of (3R)-hydroxyacyl-CoA Dehydrogenase Units.
J.Mol.Biol., 358, 2006

 

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