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4V92
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BU of 4v92 by Molmil
Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES
Descriptor: 18S RRNA, ES1, ES10, ...
Authors:Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V.
Deposit date:2014-03-21
Release date:2014-07-09
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome.
Cell(Cambridge,Mass.), 157, 2014
4V8Y
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BU of 4v8y by Molmil
Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex
Descriptor: 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ...
Authors:Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
4V9I
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BU of 4v9i by Molmil
Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S Ribosomal protein S10, ...
Authors:Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V.
Deposit date:2013-04-04
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
4V91
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BU of 4v91 by Molmil
Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES
Descriptor: 25S RRNA, 5.8S RRNA, 5S RRNA, ...
Authors:Fernandez, I.S, Bai, X, Scheres, S.H.W, Ramakrishnan, V.
Deposit date:2014-03-21
Release date:2014-07-09
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Initiation of Translation by Cricket Paralysis Virus Ires Requires its Translocation in the Ribosome.
Cell(Cambridge,Mass.), 157, 2014
4V8Z
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BU of 4v8z by Molmil
Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex
Descriptor: 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ...
Authors:Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W.
Deposit date:2013-07-20
Release date:2014-07-09
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
4JYA
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BU of 4jya by Molmil
Crystal structures of pseudouridinilated stop codons with ASLs
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V.
Deposit date:2013-03-29
Release date:2013-06-26
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (3.098 Å)
Cite:Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
4JV5
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BU of 4jv5 by Molmil
Crystal structures of pseudouridinilated stop codons with ASLs
Descriptor: 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ...
Authors:Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V.
Deposit date:2013-03-25
Release date:2013-06-26
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (3.162 Å)
Cite:Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
4K0K
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BU of 4k0k by Molmil
Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V.
Deposit date:2013-04-04
Release date:2013-06-26
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
3FIM
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BU of 3fim by Molmil
Crystal structure of aryl-alcohol-oxidase from Pleurotus eryingii
Descriptor: Aryl-alcohol oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Fernandez, I.S.
Deposit date:2008-12-12
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Novel structural features in the GMC family of oxidoreductases revealed by the crystal structure of fungal aryl-alcohol oxidase
Acta Crystallogr.,Sect.D, 65, 2009
3BSQ
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BU of 3bsq by Molmil
Crystal structure of human kallikrein 7 produced as a secretion protein in E.coli
Descriptor: Kallikrein-7, SULFATE ION
Authors:Fernandez, I.S, Standker, L, Magert, H.J, Forssmann, W.G, Gimenez-Gallego, G, Romero, A.
Deposit date:2007-12-26
Release date:2008-04-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6)
J.Mol.Biol., 377, 2008
3JUT
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BU of 3jut by Molmil
Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid
Descriptor: 2,5-dihydroxybenzoic acid, Heparin-binding growth factor 1
Authors:Fernandez, I.S, Gimenez-Gallego, G, Romero, A.
Deposit date:2009-09-15
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285, 2010
7UFI
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BU of 7ufi by Molmil
VchTnsC AAA+ ATPase with DNA, single heptamer
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*CP*TP*CP*CP*AP*GP*TP*AP*CP*AP*GP*CP*GP*CP*GP*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*AP*GP*CP*CP*GP*CP*GP*CP*TP*GP*TP*AP*CP*TP*GP*GP*AP*G)-3'), ...
Authors:Fernandez, I.S, Sternberg, S.H.
Deposit date:2022-03-22
Release date:2022-06-08
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Selective TnsC recruitment enhances the fidelity of RNA-guided transposition.
Nature, 609, 2022
7UFM
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BU of 7ufm by Molmil
VchTnsC AAA+ with DNA (double heptamer)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (36-MER), VchTnsC
Authors:Fernandez, I.S, Sternberg, S.H.
Deposit date:2022-03-22
Release date:2022-06-08
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Selective TnsC recruitment enhances the fidelity of RNA-guided transposition.
Nature, 609, 2022
6UZ7
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BU of 6uz7 by Molmil
K.lactis 80S ribosome with p/PE tRNA and eIF5B
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ...
Authors:Fernandez, I.S, Huang, B.Y.
Deposit date:2019-11-14
Release date:2020-01-15
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation.
Proc.Natl.Acad.Sci.USA, 117, 2020
2YMZ
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BU of 2ymz by Molmil
Crystal structure of chicken Galectin 2
Descriptor: GALECTIN 2, SULFATE ION, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Fernandez, I.S, Ruiz, F.M, Solis, D, Gabius, H.-J, Romero, A.
Deposit date:2012-10-11
Release date:2013-08-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Fine-Tuning of Prototype Chicken Galectins: Structure of Cg-2 and Structure-Activity Correlations
Acta Crystallogr.,Sect.D, 69, 2013
3K1X
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BU of 3k1x by Molmil
Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate
Descriptor: 2,5-dihydroxybenzenesulfonic acid, Heparin-binding growth factor 1
Authors:Romero, A, Fernandez, I.S, Gimenez-Gallego, G.
Deposit date:2009-09-29
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
J.Biol.Chem., 285, 2010
4V9H
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BU of 4v9h by Molmil
Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Tourigny, D.S, Fernandez, I.S, Kelley, A.C, Ramakrishnan, V.
Deposit date:2013-03-25
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.857 Å)
Cite:Elongation factor G bound to the ribosome in an intermediate state of translocation.
Science, 340, 2013
7TQL
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BU of 7tql by Molmil
CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Lapointe, C.P, Grosely, R, Sokabe, M, Alvarado, C, Wang, J, Montabana, E, Villa, N, Shin, B, Dever, T, Fraser, C, Fernandez, I.S, Puglisi, J.D.
Deposit date:2022-01-26
Release date:2022-04-27
Last modified:2022-12-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Nature, 607, 2022
6D9J
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BU of 6d9j by Molmil
Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.
Descriptor: 18S rRNA, 28S rRNA, 5.8S rRNA, ...
Authors:Pisareva, V.P, Pisarev, A.V, Fernandez, I.S.
Deposit date:2018-04-30
Release date:2018-06-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
4KHP
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BU of 4khp by Molmil
Structure of the Thermus thermophilus 30S ribosomal subunit in complex with de-6-MSA-pactamycin
Descriptor: 16S Ribosomal RNA, 30S Ribosomal protein S10, 30S Ribosomal protein S11, ...
Authors:Tourigny, D.S, Fernandez, I.S, Kelley, A.C, Ramakrishnan, V.
Deposit date:2013-05-01
Release date:2013-06-05
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit.
J.Mol.Biol., 425, 2013
6D90
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BU of 6d90 by Molmil
Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.
Descriptor: 18S rRNA, 28S rRNA, 5.8S rRNA, ...
Authors:Pisareva, V.P, Pisarev, A.V, Fernandez, I.S.
Deposit date:2018-04-27
Release date:2018-06-06
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
4LD9
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BU of 4ld9 by Molmil
Crystal structure of the N-terminally acetylated BAH domain of Sir3 bound to the nucleosome core particle
Descriptor: Histone H2A, Histone H2B 1.1, Histone H3.2, ...
Authors:Arnaudo, N, Fernandez, I.S, McLaughlin, S.H, Peak-Chew, S.Y, Rhodes, D, Martino, F.
Deposit date:2013-06-24
Release date:2013-08-14
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (3.306 Å)
Cite:The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle.
Nat.Struct.Mol.Biol., 20, 2013
6W2S
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BU of 6w2s by Molmil
Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1)
Descriptor: 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ...
Authors:Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S.
Deposit date:2020-03-08
Release date:2020-04-22
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
Elife, 9, 2020
6W2T
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BU of 6w2t by Molmil
Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2)
Descriptor: 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ...
Authors:Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S.
Deposit date:2020-03-08
Release date:2020-04-22
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
Elife, 9, 2020
6WOO
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BU of 6woo by Molmil
CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal rRNA, ...
Authors:Wang, J, Wang, J, Puglisi, J, Fernandez, I.S.
Deposit date:2020-04-25
Release date:2020-09-23
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:An active role of the eukaryotic large ribosomal subunit in translation initiation fidelity.
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