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IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization
Descriptor:	Baculoviral IAP repeat-containing protein 2, ZINC ION
Authors:	Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J.
Deposit date:	2011-07-28
Release date:	2011-11-02
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.897 Å)
Cite:	Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 334, 2011

Crystal structure of XIAP BIR3 with CS3
Descriptor:	(3S)-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-3-methyl-N-(2-pyrimidin-2-ylphenyl)-L-prolinamide, Baculoviral IAP repeat-containing protein 4, ZINC ION
Authors:	Hymowitz, S.G.
Deposit date:	2009-05-26
Release date:	2009-06-16
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. Acs Chem.Biol., 4, 2009