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6UFR
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BU of 6ufr by Molmil
Structure of recombinantly assembled E46K alpha-synuclein fibrils
Descriptor: Alpha-synuclein
Authors:Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L.
Deposit date:2019-09-24
Release date:2020-02-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc.Natl.Acad.Sci.USA, 117, 2020
8DUW
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BU of 8duw by Molmil
HnRNPA2 D290V LCD PM2
Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R.
Deposit date:2022-07-27
Release date:2023-08-02
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
8DU2
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BU of 8du2 by Molmil
HnRNPA2 D290V LCD PM1
Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R.
Deposit date:2022-07-26
Release date:2023-08-02
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
8EC7
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BU of 8ec7 by Molmil
HnRNPA2 D290V LCD PM3
Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R.
Deposit date:2022-09-01
Release date:2023-09-06
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
6N4P
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BU of 6n4p by Molmil
RQEFEV, crystal structure of the N-terminal segment RQEFEV from protein tau
Descriptor: Microtubule-associated protein tau
Authors:Eisenberg, D.S, Boyer, D.R.
Deposit date:2018-11-19
Release date:2019-11-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A structure-based model for the electrostatic interaction of the N-terminus of protein tau with the fibril core of Alzheimer's Disease filaments
Biorxiv, 2021
6ODG
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BU of 6odg by Molmil
SVQIVY, Crystal Structure of a tau protein fragment
Descriptor: Microtubule-associated protein tau
Authors:Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M.
Deposit date:2019-03-26
Release date:2019-10-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J.Biol.Chem., 294, 2019
7UPE
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BU of 7upe by Molmil
Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG
Descriptor: Isoform Tau-F of Microtubule-associated protein tau
Authors:Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2022-04-15
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
7UPG
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BU of 7upg by Molmil
Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours
Descriptor: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, Isoform Tau-F of Microtubule-associated protein tau
Authors:Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2022-04-15
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
7UPF
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BU of 7upf by Molmil
Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG
Descriptor: Isoform Tau-F of Microtubule-associated protein tau
Authors:Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2022-04-15
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
Nat Commun, 13, 2022
6VW2
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BU of 6vw2 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils
Descriptor: Islet amyloid polypeptide (SUMO-tagged)
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2020-02-18
Release date:2020-06-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
Nat.Struct.Mol.Biol., 27, 2020
6WQK
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BU of 6wqk by Molmil
hnRNPA2 Low complexity domain (LCD) determined by cryoEM
Descriptor: MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera
Authors:Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2020-04-29
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
6WPQ
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BU of 6wpq by Molmil
GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant
Descriptor: Heterogeneous nuclear ribonucleoprotein A2
Authors:Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2020-04-27
Release date:2020-08-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
8FQ7
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BU of 8fq7 by Molmil
Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils
Descriptor: GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils
Authors:Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S.
Deposit date:2023-01-05
Release date:2023-10-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
8TEQ
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BU of 8teq by Molmil
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber
Descriptor: TRK-fused gene protein Low Complexity Domain G269V mutant
Authors:Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S.
Deposit date:2023-07-06
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
Pnas Nexus, 2, 2023
8TER
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BU of 8ter by Molmil
Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber
Descriptor: TRK-fused gene protein Low Complexity Domain P285L mutant
Authors:Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S.
Deposit date:2023-07-06
Release date:2023-12-20
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
Pnas Nexus, 2, 2023
4XFO
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BU of 4xfo by Molmil
Structure of an amyloid-forming segment TAVVTN from human Transthyretin
Descriptor: Amyloid-forming peptide TAVVTN
Authors:Saelices, L, Sawaya, M, Cascio, D, Eisenberg, D.S.
Deposit date:2014-12-27
Release date:2015-10-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
4XFN
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BU of 4xfn by Molmil
Structure of an Amyloid forming peptide AEVVFT from Human Transthyretin
Descriptor: Amyloid forming peptide AEVVFT
Authors:Saelices, L, Sawaya, M, Cascio, D, Eisenberg, D.S.
Deposit date:2014-12-27
Release date:2015-10-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
4ZNN
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BU of 4znn by Molmil
MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56
Descriptor: Alpha-synuclein
Authors:Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S.
Deposit date:2015-05-05
Release date:2015-09-09
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.41 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
5ACL
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BU of 5acl by Molmil
Mcg immunoglobulin variable domain with sulfasalazine
Descriptor: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, MCG, SULFATE ION
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015
5ACM
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BU of 5acm by Molmil
Mcg immunoglobulin variable domain with methylene blue
Descriptor: 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ...
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015
7SP1
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BU of 7sp1 by Molmil
RNA-induced tau amyloid fibril
Descriptor: Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')
Authors:Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S.
Deposit date:2021-11-02
Release date:2022-03-30
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SXN
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BU of 7sxn by Molmil
Orb2A residues 1-9 MYNKFVNFI
Descriptor: Orb2A residues 1-9 MYNKFVNFI
Authors:Bowler, J.T, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2021-11-23
Release date:2022-10-05
Last modified:2023-06-14
Method:ELECTRON CRYSTALLOGRAPHY (1.05 Å)
Cite:Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets.
J.Biol.Chem., 298, 2022
5K2G
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BU of 5k2g by Molmil
Structure of GNNQQNY from yeast prion Sup35 in space group P21 determined by MicroED
Descriptor: Eukaryotic peptide chain release factor GTP-binding subunit
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S.
Deposit date:2016-05-18
Release date:2016-09-14
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.1 Å)
Cite:Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KO0
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BU of 5ko0 by Molmil
Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED
Descriptor: THIOCYANATE ION, hIAPP(15-25)WT
Authors:Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S.
Deposit date:2016-06-28
Release date:2016-12-21
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.4 Å)
Cite:Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.
Elife, 6, 2017
3RUB
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BU of 3rub by Molmil
CRYSTAL STRUCTURE OF THE UNACTIVATED FORM OF RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE(SLASH)OXYGENASE FROM TOBACCO REFINED AT 2.0-ANGSTROMS RESOLUTION
Descriptor: ASPARAGINE, RIBULOSE 1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE, FORM III, ...
Authors:Schreuder, H, Cascio, D, Curmi, P.M.G, Chapman, M.S, Suh, S.W, Eisenberg, D.S.
Deposit date:1990-05-25
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the unactivated form of ribulose-1,5-bisphosphate carboxylase/oxygenase from tobacco refined at 2.0-A resolution.
J.Biol.Chem., 267, 1992

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