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3HVN
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BU of 3hvn by Molmil
Crystal structure of cytotoxin protein suilysin from Streptococcus suis
Descriptor: 1,1,1,3,3,3-hexafluoropropan-2-ol, HEPTANE-1,2,3-TRIOL, Hemolysin
Authors:Xu, L, Huang, B, Du, H, Zhang, C.X, Xu, J, Li, X, Rao, Z.
Deposit date:2009-06-16
Release date:2010-03-02
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.852 Å)
Cite:Crystal structure of cytotoxin protein suilysin from Streptococcus suis.
Protein Cell, 1, 2010
5IM8
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BU of 5im8 by Molmil
Solution Structure of the Microtubule-Targeting COS Domain of MID1
Descriptor: E3 ubiquitin-protein ligase Midline-1
Authors:Wright, K.M, Du, H, Dagnachew, M, Massiah, M.A.
Deposit date:2016-03-05
Release date:2016-07-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of the microtubule-targeting COS domain of MID1.
Febs J., 283, 2016
3GGQ
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BU of 3ggq by Molmil
Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction
Descriptor: BROMIDE ION, Capsid protein
Authors:Li, S.W, Tang, X.H, Seetharaman, J, Yang, C.Y, Gu, Y, Zhang, J, Du, H.L, Shih, J.W.K, Hew, C.L, Sivaraman, J, Xia, N.S.
Deposit date:2009-03-02
Release date:2009-08-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction
Plos Pathog., 5, 2009
8T5C
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BU of 8t5c by Molmil
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8.11G Heavy Chain, 8.11G Light Chain, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2023-06-13
Release date:2024-01-03
Last modified:2024-01-24
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Nat Commun, 15, 2024
5T04
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BU of 5t04 by Molmil
STRUCTURE OF CONSTITUTIVELY ACTIVE NEUROTENSIN RECEPTOR
Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, ARG-ARG-PRO-TYR-ILE-LEU, DI(HYDROXYETHYL)ETHER, ...
Authors:Krumm, B, Botos, I, Grisshammer, R.
Deposit date:2016-08-15
Release date:2016-12-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure and dynamics of a constitutively active neurotensin receptor.
Sci Rep, 6, 2016
4ANM
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BU of 4anm by Molmil
Complex of CK2 with a CDC7 inhibitor
Descriptor: 8-BROMANYL-2-[[(3S)-3-OXIDANYLPYRROLIDIN-1-YL]METHYL]-3H-[1]BENZOFURO[3,2-D]PYRIMIDIN-4-ONE, CASEIN KINASE II SUBUNIT ALPHA
Authors:Stout, T.J.
Deposit date:2012-03-20
Release date:2012-05-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Xl413, a Potent and Selective Cdc7 Inhibitor.
Bioorg.Med.Chem.Lett., 22, 2012
4ALW
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BU of 4alw by Molmil
Benzofuropyrimidinone Inhibitors of Pim-1
Descriptor: 8-BROMANYL-2-[(4-METHYLPIPERAZIN-1-YL)METHYL]-3H-[1]BENZOFURO[3,2-D]PYRIMIDIN-4-ONE, IMIDAZOLE, PIM-1 KINASE
Authors:Stout, T.J, Adams, L.
Deposit date:2012-03-05
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4ALU
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BU of 4alu by Molmil
Benzofuropyrimidinone Inhibitors of Pim-1
Descriptor: 8-bromo-2-(2-chlorophenyl)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, IMIDAZOLE, SERINE/THREONINE-PROTEIN KINASE PIM-1
Authors:Stout, T.J, Adams, L.
Deposit date:2012-03-05
Release date:2013-01-16
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4ALV
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BU of 4alv by Molmil
Benzofuropyrimidinone Inhibitors of Pim-1
Descriptor: 8-bromo-2-{2-chloro-4-[(piperidin-4-ylmethyl)amino]phenyl}[1]benzofuro[3,2-d]pyrimidin-4(3H)-one, IMIDAZOLE, SERINE/THREONINE-PROTEIN KINASE PIM-1
Authors:Stout, T.J, Adams, L.
Deposit date:2012-03-05
Release date:2013-01-16
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4BBE
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BU of 4bbe by Molmil
Aminoalkylpyrimidine Inhibitor Complexes with JAK2
Descriptor: N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide, TYROSINE-PROTEIN KINASE JAK2
Authors:Li, J.
Deposit date:2012-09-21
Release date:2012-11-21
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
4BBF
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BU of 4bbf by Molmil
Aminoalkylpyrimidine Inhibitor Complexes with JAK2
Descriptor: (2R)-N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide, TYROSINE-PROTEIN KINASE JAK2
Authors:Li, J.
Deposit date:2012-09-21
Release date:2012-11-21
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
8HF2
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BU of 8hf2 by Molmil
Cryo-EM structure of WeiTsing
Descriptor: PRA1 family protein
Authors:Qin, L, Tang, L.H, Chen, Y.H.
Deposit date:2022-11-09
Release date:2023-06-21
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance.
Cell, 186, 2023
7MF0
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BU of 7mf0 by Molmil
Co-crystal structure of PERK with inhibitor (R)-2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide
Descriptor: 2-amino-N-cyclopropyl-5-(4-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}-2-methylphenyl)pyridine-3-carboxamide, Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Wiens, B, Koszelak-Rosenblum, M, Surman, M.D, Zhu, G, Mulvihill, M.J.
Deposit date:2021-04-08
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.809 Å)
Cite:Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors.
Bioorg.Med.Chem.Lett., 43, 2021
8EQE
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BU of 8eqe by Molmil
Co-crystal structure of PERK with compound 26
Descriptor: (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetamide, Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Zhu, G, Surman, M.D, Mulvihill, M.J.
Deposit date:2022-10-07
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.559 Å)
Cite:Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.
Pharmaceutics, 14, 2022
8EQ9
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BU of 8eq9 by Molmil
Co-crystal structure of PERK with compound 11
Descriptor: (2R)-N-[(4M)-4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide, Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Zhu, G, Surman, M.D, Mulvihill, M.J.
Deposit date:2022-10-07
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.
Pharmaceutics, 14, 2022
8EQD
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BU of 8eqd by Molmil
Co-crystal structure of PERK with compound 24
Descriptor: (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide, Eukaryotic translation initiation factor 2-alpha kinase 3
Authors:Zhu, G, Surman, M.D, Mulvihill, M.J.
Deposit date:2022-10-07
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors.
Pharmaceutics, 14, 2022
6AY9
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BU of 6ay9 by Molmil
Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide
Descriptor: CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 6, HIV-1 capsid protein, ...
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-07
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
6B2K
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BU of 6b2k by Molmil
E45A/R132T mutant of HIV-1 capsid protein
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
6AYA
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BU of 6aya by Molmil
Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION, ...
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-07
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
6B2J
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BU of 6b2j by Molmil
E45A mutant of HIV-1 capsid protein (other crystal form)
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
6B2G
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BU of 6b2g by Molmil
P38A mutant of HIV-1 capsid protein
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.407 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
6B2I
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BU of 6b2i by Molmil
E45A mutant of the HIV-1 capsid protein
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
6B2H
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BU of 6b2h by Molmil
P38A/T216I mutant of the HIV-1 capsid protein
Descriptor: CHLORIDE ION, HIV-1 capsid protein, IODIDE ION
Authors:Gres, A.T, Kirby, K.A, Sarafianos, S.G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization.
Nat Commun, 14, 2023
7WEG
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BU of 7weg by Molmil
Complex structure of PDZD7 and FCHSD2
Descriptor: FCHSD2, PDZ domain-containing protein 7, ZINC ION
Authors:Wang, H, Lin, L, Lu, Q.
Deposit date:2021-12-23
Release date:2022-11-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2.
Biochem.J., 479, 2022

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