1ZPB
 
 | | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide | | Descriptor: | 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE, Coagulation factor XI, SULFATE ION | | Authors: | Deng, H, Bannister, T.D, Jin, L, Nagafuji, P, Celatka, C.A, Lin, J, Lazarova, T.I, Rynkiewicz, M.J, Quinn, J, Bibbins, F, Pandey, P, Gorga, J, Babine, R.E, Meyers, H.V, Abdel-Meguid, S.S, Strickler, J.E. | | Deposit date: | 2005-05-16 | | Release date: | 2006-04-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine
Bioorg.Med.Chem.Lett., 16, 2006
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1ZPC
 | | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide | | Descriptor: | 2-[2-(3-CHLORO-PHENYL)-2-HYDROXY-ACETYLAMINO]-N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-3-METHYL-BUTYRAMIDE, Coagulation factor XI, SULFATE ION | | Authors: | Deng, H, Bannister, T.D, Jin, L, Nagafuji, P, Celatka, C.A, Lin, J, Lazarova, T.I, Rynkiewicz, M.J, Quinn, J, Bibbins, F, Pandey, P, Gorga, J, Babine, R.E, Meyers, H.V, Abdel-Meguid, S.S, Strickler, J.E. | | Deposit date: | 2005-05-16 | | Release date: | 2006-04-18 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine
Bioorg.Med.Chem.Lett., 16, 2006
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2WR8
 | | Structure of Pyrococcus horikoshii SAM hydroxide adenosyltransferase in complex with SAH | | Descriptor: | PUTATIVE UNCHARACTERIZED PROTEIN PH0463, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | McMahon, S.A, Deng, H, O'Hagan, D, Johnson, K.A, Naismith, J.H. | | Deposit date: | 2009-08-31 | | Release date: | 2009-09-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Mechanistic Insights Into Water Activation in Sam Hydroxide Adenosyltransferase (Duf-62).
Chembiochem, 10, 2009
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1DRO
 | | NMR STRUCTURE OF THE CYTOSKELETON/SIGNAL TRANSDUCTION PROTEIN | | Descriptor: | BETA-SPECTRIN | | Authors: | Zhang, P, Talluri, S, Deng, H, Branton, D, Wagner, G. | | Deposit date: | 1995-09-29 | | Release date: | 1996-04-03 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the pleckstrin homology domain of Drosophila beta-spectrin.
Structure, 3, 1995
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1ZOM
 | | Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor | | Descriptor: | (S)-2-(3-((R)-1-(4-BROMOPHENYL)ETHYL)UREIDO)-N-((S)-1-((S)-5-GUANIDINO-1-OXO-1-(THIAZOL-2-YL)PENTAN-2-YLAMINO)-3-METHYL-1-OXOBUTAN-2-YL)-5-UREIDOPENTANAMIDE, Coagulation factor XI, SULFATE ION | | Authors: | Lin, J, Deng, H, Jin, L, Pandey, P, Rynkiewicz, M, Bibbins, F, Cantin, S, Quinn, J, Magee, S, Gorga, J. | | Deposit date: | 2005-05-13 | | Release date: | 2006-05-23 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
J.Med.Chem., 49, 2006
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1RQP
 | | Crystal structure and mechanism of a bacterial fluorinating enzyme | | Descriptor: | 5'-fluoro-5'-deoxyadenosine synthase, S-ADENOSYLMETHIONINE | | Authors: | Dong, C, Huang, F, Deng, H, Schaffrath, C, Spencer, J.B, O'Hagan, D, Naismith, J.H. | | Deposit date: | 2003-12-06 | | Release date: | 2004-03-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature, 427, 2004
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1RQR
 | | Crystal structure and mechanism of a bacterial fluorinating enzyme, product complex | | Descriptor: | 5'-FLUORO-5'-DEOXYADENOSINE, 5'-fluoro-5'-deoxyadenosine synthase, METHIONINE | | Authors: | Dong, C, Huang, F, Deng, H, Schaffrath, C, Spencer, J.B, O'Hagan, D, Naismith, J.H. | | Deposit date: | 2003-12-07 | | Release date: | 2004-03-02 | | Last modified: | 2022-06-15 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature, 427, 2004
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2N5C
 | | Solution NMR structure of the lasso peptide chaxapeptin | | Descriptor: | chaxapeptin | | Authors: | Elsayed, S.S, Trusch, F, Deng, H, Raab, A, Prokes, I, Busarakam, K, Asenjo, J.A, Andrews, B.A, van West, P, Bull, A.T, Goodfellow, M, Yi, Y, Ebel, R, Jaspars, M, Rateb, M.E. | | Deposit date: | 2015-07-14 | | Release date: | 2015-10-07 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert.
J.Org.Chem., 80, 2015
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3J2E
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (15.3 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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3J2D
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (18.700001 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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3J28
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (12.9 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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3J2G
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (16.5 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic Acids Res., 41, 2013
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3J2C
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA body domain, 16S rRNA head domain | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (13.2 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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3J29
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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3J2F
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (17.6 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic Acids Res., 41, 2013
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3J2H
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (18.799999 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic Acids Res., 41, 2013
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3J2B
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (13.6 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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3J2A
 | | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM | | Descriptor: | 16S rRNA | | Authors: | Guo, Q, Goto, S, Chen, Y, Muto, A, Himeno, H, Deng, H, Lei, J, Gao, N. | | Deposit date: | 2012-09-28 | | Release date: | 2013-01-16 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (13.1 Å) | | Cite: | Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
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1ZPZ
 | | Factor XI catalytic domain complexed with N-((R)-1-(4-bromophenyl)ethyl)urea-Asn-Val-Arg-alpha-ketothiazole | | Descriptor: | Coagulation factor XI, N~2~-({[(1R)-1-(4-BROMOPHENYL)ETHYL]AMINO}CARBONYL)ASPARAGINYL-N~1~-{4-{[AMINO(IMINO)METHYL]AMINO}-1-[2,3-DIHYDRO-1,3-THIAZOL-2-YL(HYDROXY)METHYL]BUTYL}VALINAMIDE, SULFATE ION | | Authors: | Lin, J, Deng, H, Jin, L, Prandey, P, Rynkiewicz, M.J, Bibbins, F, Cantin, S, Quinn, J, Magee, S, Gorga, J. | | Deposit date: | 2005-05-18 | | Release date: | 2006-05-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Design, Synthesis and Biological Evaluation of Peptidomimetic FXIa Inhibitors
To be Published
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2C4U
 | | Crystal structure of the apo form of the 5'-Fluoro-5'-deoxyadenosine synthase enzyme from Streptomyces cattleya | | Descriptor: | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, GLYCEROL | | Authors: | McEwan, A.R, Deng, H, Robinson, D.A, DeLaurentis, W, McGlinchey, R.P, O'Hagan, D, Naismith, J.H. | | Deposit date: | 2005-10-22 | | Release date: | 2006-04-12 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
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2C5B
 | | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-5'deoxy-fluoroadenosine. | | Descriptor: | 5'-FLUORO-2',5'-DIDEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, METHIONINE | | Authors: | McEwan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.A, O'Hagan, D, Naismith, J.H, Spencer, J. | | Deposit date: | 2005-10-26 | | Release date: | 2007-02-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Substrate Specificity in Enzymatic Fluorination. The Fluorinase from Streptomyces Cattleya Accepts 2'-Deoxyadenosine Substrates.
Org.Biomol.Chem., 4, 2006
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2C4T
 | | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with an inhibitor, an analogue of S- adenosyl methionine | | Descriptor: | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION, S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE | | Authors: | McEwan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Naismith, J.H. | | Deposit date: | 2005-10-22 | | Release date: | 2007-03-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Substrates and Inhibitors of the Fluorinase from Streptomyces Cattleya
To be Published
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2C5H
 | | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-adenosine | | Descriptor: | (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION, ... | | Authors: | McEwan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Naismith, J.H, Spencer, J. | | Deposit date: | 2005-10-27 | | Release date: | 2006-10-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Substrates and Inhibitors of the Fluorinase from Streptomyces Cattleya
To be Published
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2CBX
 | | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with beta-D-erythrofuranosyl- adenosine | | Descriptor: | 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, BETA-D-ERYTHROFURANOSYL-ADENOSINE, GLYCEROL | | Authors: | McEwan, A.R, Cadicamo, C.D, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Naismith, J.H, Spencer, J. | | Deposit date: | 2006-01-09 | | Release date: | 2007-03-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
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2CC2
 | | X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 5'deoxyadenosine | | Descriptor: | 5'-DEOXYADENOSINE, 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE, CHLORIDE ION | | Authors: | Mcewan, A.R, Deng, H, McGlinchey, R.P, Robinson, D.R, O'Hagan, D, Spencer, J, Naismith, J.H. | | Deposit date: | 2006-01-11 | | Release date: | 2007-03-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.
Org. Biomol. Chem., 4, 2006
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