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6EHT
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BU of 6eht by Molmil
Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme
Descriptor: DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), PCNA-associated factor, ...
Authors:De March, M, Barrera-Vilarmau, S, Mentegari, E, Merino, N, Bressan, E, Maga, G, Crehuet, R, Onesti, S, Blanco, F.J, De Biasio, A.
Deposit date:2017-09-15
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
6GIS
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BU of 6gis by Molmil
Structural basis of human clamp sliding on DNA
Descriptor: DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), Proliferating cell nuclear antigen
Authors:De March, M, Merino, N, Barrera-Vilarmau, S, Crehuet, R, Onesti, S, Blanco, F.J, De Biasio, A.
Deposit date:2018-05-15
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural basis of human PCNA sliding on DNA.
Nat Commun, 8, 2017
6HVO
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BU of 6hvo by Molmil
Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta
Descriptor: DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION
Authors:Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A.
Deposit date:2018-10-11
Release date:2019-01-23
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA).
J.Biol.Chem., 294, 2019
6GWS
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BU of 6gws by Molmil
Crystal structure of human PCNA in complex with three p15 peptides
Descriptor: PCNA-associated factor, Proliferating cell nuclear antigen
Authors:De March, M, Merino, N, Gonzalez-Magana, A, Romano-Moreno, M, Onesti, S, Blanco, F.J, De Biasio, A.
Deposit date:2018-06-25
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
7QO1
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BU of 7qo1 by Molmil
complex of DNA ligase I and FEN1 on PCNA and DNA
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Flap endonuclease 1, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
7QNZ
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BU of 7qnz by Molmil
human Lig1-DNA-PCNA complex reconstituted in absence of ATP
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ...
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2021-12-23
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.58 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
8B8T
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BU of 8b8t by Molmil
Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP
Descriptor: DNA ligase 1, Proliferating cell nuclear antigen
Authors:Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A.
Deposit date:2022-10-05
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Nat Commun, 13, 2022
6S1M
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BU of 6s1m by Molmil
Human polymerase delta holoenzyme Conformer 1
Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
Authors:Lancey, C, Hamdan, S.M, De Biasio, A.
Deposit date:2019-06-19
Release date:2019-12-25
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (4.27 Å)
Cite:Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6S1N
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BU of 6s1n by Molmil
Human polymerase delta holoenzyme Conformer 2
Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
Authors:Lancey, C, Hamdan, S.M, De Biasio, A.
Deposit date:2019-06-19
Release date:2019-12-25
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (4.86 Å)
Cite:Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
3OP8
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BU of 3op8 by Molmil
Crystal structure of the domain V from beta2-glycoprotein I
Descriptor: Beta-2-glycoprotein 1, SULFATE ION
Authors:Kolyada, A, Lee, C.-J, De Biasio, A, Beglova, N.
Deposit date:2010-08-31
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome.
Plos One, 5, 2010
7NV1
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BU of 7nv1 by Molmil
Human Pol Kappa holoenzyme with Ub-PCNA
Descriptor: DNA Primer, DNA Template, DNA polymerase kappa, ...
Authors:Lancey, C, De Biasio, A, Hamdan, S.M.
Deposit date:2021-03-15
Release date:2021-11-03
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Nat Commun, 12, 2021
7NV0
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BU of 7nv0 by Molmil
Human Pol Kappa holoenzyme with wt PCNA
Descriptor: DNA Primer, DNA Template, DNA polymerase kappa, ...
Authors:Lancey, C, De Biasio, A, Hamdan, S.M.
Deposit date:2021-03-15
Release date:2021-11-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA.
Nat Commun, 12, 2021
6S1O
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BU of 6s1o by Molmil
Human polymerase delta holoenzyme Conformer 3
Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
Authors:Lancey, C, Hamdan, S.M, De Biasio, A.
Deposit date:2019-06-19
Release date:2019-12-25
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (8.1 Å)
Cite:Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6TNZ
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BU of 6tnz by Molmil
Human polymerase delta-FEN1-PCNA toolbelt
Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
Authors:Lancey, C, Hamdan, S.M, De Biasio, A.
Deposit date:2019-12-10
Release date:2019-12-18
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (4.05 Å)
Cite:Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6TNY
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BU of 6tny by Molmil
Processive human polymerase delta holoenzyme
Descriptor: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
Authors:Lancey, C, Hamdan, S.M, De Biasio, A.
Deposit date:2019-12-10
Release date:2019-12-18
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
4D2G
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BU of 4d2g by Molmil
Crystal structure of human PCNA in complex with p15 peptide
Descriptor: P15, PROLIFERATING CELL NUCLEAR ANTIGEN
Authors:DeBiasio, A, Ibanez, A, Mortuza, G, Molina, R, Cordeiro, T.N, Castillo, F, Villate, M, Merino, N, Lelli, M, Diercks, T, Luque, I, Bernardo, P, Montoya, G, Blanco, F.J.
Deposit date:2014-05-09
Release date:2015-03-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair.
Nat.Commun., 6, 2015
4ZTD
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BU of 4ztd by Molmil
Crystal Structure of Human PCNA in complex with a TRAIP peptide
Descriptor: ALA-GLY-ALA-GLY-ALA, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, Proliferating cell nuclear antigen
Authors:Montoya, G, Mortuza, G.B, Blanco, F.J, Ibanez de Opakua, A.
Deposit date:2015-05-14
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
J.Cell Biol., 212, 2016
2KRI
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BU of 2kri by Molmil
Structure of a complex between domain V of beta2-glycoprotein I and the fourth ligand-binding module from LDLR determined with Haddock
Descriptor: Beta-2-glycoprotein 1, CALCIUM ION, Low-density lipoprotein receptor
Authors:Beglova, N.
Deposit date:2009-12-18
Release date:2010-03-31
Last modified:2019-11-06
Method:SOLUTION NMR
Cite:Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids.
Structure, 18, 2010

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