Author results

3EJB
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CRYSTAL STRUCTURE OF P450BIOI IN COMPLEX WITH TETRADECANOIC ACID LIGATED ACYL CARRIER PROTEIN
Descriptor:Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Modification date:2016-08-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJD
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CRYSTAL STRUCTURE OF P450BIOI IN COMPLEX WITH HEXADEC-9Z-ENOIC ACID LIGATED ACYL CARRIER PROTEIN
Descriptor:Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJE
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CRYSTAL STRUCTURE OF P450BIOI IN COMPLEX WITH OCTADEC-9Z-ENOIC ACID LIGATED ACYL CARRIER PROTEIN
Descriptor:Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3MGX
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CRYSTAL STRUCTURE OF P450 OXYD THAT IS INVOLVED IN THE BIOSYNTHESIS OF VANCOMYCIN-TYPE ANTIBIOTICS
Descriptor:Putative P450 monooxygenase (E.C.1.14.14.1)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2010-04-07
Release date:2010-06-02
Modification date:2010-08-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of oxyd, a cytochrome p450 involved in {beta}-hydroxytyrosine formation in vancomycin biosynthesis
J.Biol.Chem., 285, 2010
3NC3
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CYP134A1 STRUCTURE WITH A CLOSED SUBSTRATE BINDING LOOP
Descriptor:Cytochrome P450 cypX (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Modification date:2010-09-22
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC5
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CYP134A1 STRUCTURE WITH AN OPEN SUBSTRATE BINDING LOOP
Descriptor:Cytochrome P450 cypX (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Modification date:2010-09-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC6
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CYP134A1 1-PHENYLIMIDAZOLE BOUND STRUCTURE
Descriptor:Cytochrome P450 cypX (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Modification date:2010-09-22
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC7
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CYP134A1 2-PHENYLIMIDAZOLE BOUND STRUCTURE
Descriptor:Cytochrome P450 cypX (E.C.1.14.-.-)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Modification date:2010-09-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3O1A
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STRUCTURE OF OXYE (CYP165D3), A CYTOCHROME P450 INVOLVED IN TEICOPLANIN BIOSYNTHESIS
Descriptor:Oxy protein (E.C.1.14.14.1)
Authors:Cryle, M.J., Schlichting, I.
Deposit date:2010-07-21
Release date:2010-11-03
Modification date:2011-03-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis.
Arch.Biochem.Biophys., 507, 2011
4L0E
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STRUCTURE OF P450SKY (CYP163B3), A CYTOCHROME P450 FROM SKYLLAMYCIN BIOSYNTHESIS (HEME-COORDINATED EXPRESSION TAG)
Descriptor:P450 monooxygenase (E.C.1.14.-.-)
Authors:Cryle, M.J.
Deposit date:2013-05-31
Release date:2013-09-25
Modification date:2013-11-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
4L0F
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STRUCTURE OF P450SKY (CYP163B3), A CYTOCHROME P450 FROM SKYLLAMYCIN BIOSYNTHESIS (OPEN ACTIVE SITE)
Descriptor:P450 monooxygenase (E.C.1.14.-.-)
Authors:Cryle, M.J.
Deposit date:2013-05-31
Release date:2013-09-25
Modification date:2013-11-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
5EX6
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STRUCTURE OF P450 STAH FROM GLYCOPEPTIDE ANTIBIOTIC A47934 BIOSYNTHESIS
Descriptor:Cytochrome P450
Authors:Cryle, M.J., Ulrich, V.
Deposit date:2015-11-23
Release date:2016-08-03
Modification date:2016-09-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH.
Mol Biosyst, 12, 2016
5EX8
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STRUCTURE OF P450 STAF FROM GLYCOPEPTIDE ANTIBIOTIC A47934 BIOSYNTHESIS; ETHYLENE GLYCOL CRYO
Descriptor:Cytochrome P450
Authors:Cryle, M.J., Ulrich, V.
Deposit date:2015-11-23
Release date:2017-01-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934
Beilstein J. Org. Chem., 12, 2016
5EX9
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STRUCTURE OF P450 STAF FROM GLYCOPEPTIDE ANTIBIOTIC A47934 BIOSYNTHESIS; GLYCEROL CRYO
Descriptor:Cytochrome P450
Authors:Cryle, M.J., Ulrich, V.
Deposit date:2015-11-23
Release date:2017-01-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934
Beilstein J. Org. Chem., 12, 2016
3CVU
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DROSOPHILA MELANOGASTER (6-4) PHOTOLYASE BOUND TO DS DNA WITH A T-T (6-4) PHOTOLESION
Descriptor:RE11660p/DNA Complex
Authors:Maul, M.J., Barends, T.R.M., Glas, A.F., Cryle, M.J., Schlichting, I., Carell, T.
Deposit date:2008-04-20
Release date:2008-11-04
Modification date:2009-06-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and mechanism of a DNA (6-4) photolyase.
Angew.Chem.Int.Ed.Engl., 47, 2008
3CVW
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DROSOPHILA MELANOGASTER (6-4) PHOTOLYASE H365N MUTANT BOUND TO DS DNA WITH A T-T (6-4) PHOTOLESION AND COFACTOR F0
Descriptor:RE11660p/DNA Complex
Authors:Maul, M.J., Barends, T.R.M., Glas, A.F., Cryle, M.J., Schlichting, I., Carell, T.
Deposit date:2008-04-20
Release date:2009-10-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and mechanism of a cofactor f0 accelerated (6-4) photolyase from the fruit fly
To be Published
3CVX
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DROSOPHILA MELANOGASTER (6-4) PHOTOLYASE H369M MUTANT BOUND TO DS DNA WITH A T-T (6-4) PHOTOLESION
Descriptor:RE11660p/DNA Complex
Authors:Maul, M.J., Barends, T.R.M., Glas, A.F., Cryle, M.J., Schlichting, I., Carell, T.
Deposit date:2008-04-20
Release date:2009-10-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and mechanism of a coenzyme F0 accelerated (6-4) photolyase from the fruit fly
To be Published
3CVY
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DROSOPHILA MELANOGASTER (6-4) PHOTOLYASE BOUND TO REPAIRED DS DNA
Descriptor:RE11660p/DNA Complex
Authors:Maul, M.J., Barends, T.R.M., Glas, A.F., Cryle, M.J., Schlichting, I., Carell, T.
Deposit date:2008-04-20
Release date:2008-11-04
Modification date:2009-06-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and mechanism of a DNA (6-4) photolyase.
Angew.Chem.Int.Ed.Engl., 47, 2008
2MR7
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APO STRUCTURE OF THE PEPTIDYL CARRIER PROTEIN DOMAIN 7 OF THE TEICOPLANIN PRODUCING NON-RIBOSOMAL PEPTIDE SYNTHETASE
Descriptor:Non-ribosomal peptide synthetase
Authors:Haslinger, K., Maximowitsch, E., Redfield, C., Cryle, M.J.
Deposit date:2014-07-02
Release date:2015-01-28
Modification date:2015-04-08
Method:SOLUTION NMR
Cite:Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis.
Proteins, 83, 2015
2MR8
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HOLO STRUCTURE OF THE PEPTIDYL CARRIER PROTEIN DOMAIN 7 OF THE TEICOPLANIN PRODUCING NON-RIBOSOMAL PEPTIDE SYNTHETASE
Descriptor:Non-ribosomal peptide synthetase
Authors:Haslinger, K., Maximowitsch, E., Redfield, C., Cryle, M.J.
Deposit date:2014-07-02
Release date:2015-01-28
Modification date:2015-04-08
Method:SOLUTION NMR
Cite:Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis.
Proteins, 83, 2015
4PWV
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STRUCTURE OF P450SKY (CYP163B3), A CYTOCHROME P450 FROM SKYLLAMYCIN BIOSYNTHESIS IN COMPLEX WITH A PEPTIDYL CARRIER PROTEIN DOMAIN
Descriptor:P450 monooxygenase (E.C.1.14.14.1), Peptide synthetase
Authors:Haslinger, K., Cryle, M.J.
Deposit date:2014-03-21
Release date:2014-07-23
Modification date:2014-08-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of a transient complex of a nonribosomal Peptide synthetase and a cytochrome p450 monooxygenase.
Angew.Chem.Int.Ed.Engl., 53, 2014
4PXH
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STRUCTURE OF P450SKY (CYP163B3), A CYTOCHROME P450 FROM SKYLLAMYCIN BIOSYNTHESIS IN COMPLEX WITH A PEPTIDYL CARRIER PROTEIN DOMAIN
Descriptor:P450 monooxygenase (E.C.1.14.14.1), Peptide synthetase
Authors:Haslinger, K., Cryle, M.J.
Deposit date:2014-03-24
Release date:2014-07-23
Modification date:2014-08-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure of a transient complex of a nonribosomal Peptide synthetase and a cytochrome p450 monooxygenase.
Angew.Chem.Int.Ed.Engl., 53, 2014
4RM4
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THE CRYSTAL STRUCTURE OF THE VERSATILE CYTOCHROME P450 ENZYME CYP109B1 FROM BACILLUS SUBTILIS
Descriptor:Cytochrome P450 (E.C.1.14.-.-)
Authors:Zhouw, W.H., Zhang, A.L., Zhang, T., Hall, E.A., Hutchinson, S., Cryle, M.J., Wong, L.-L., Bell, S.G.
Deposit date:2014-10-18
Release date:2015-02-04
Modification date:2015-03-04
Method:X-RAY DIFFRACTION (1.771 Å)
Cite:The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis.
Mol Biosyst, 11, 2015
4TVF
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OXYB FROM ACTINOPLANES TEICHOMYCETICUS
Descriptor:OxyB (E.C.1.14.14.1)
Authors:Haslinger, K., Cryle, M.J.
Deposit date:2014-06-26
Release date:2014-11-12
Modification date:2014-12-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cytochrome P450 OxyBtei Catalyzes the First Phenolic Coupling Step in Teicoplanin Biosynthesis.
Chembiochem, 15, 2014
4TX2
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CRYSTAL STRUCTURE OF THE X-DOMAIN FROM TEICOPLANIN BIOSYNTHESIS
Descriptor:X-domain from Tcp12
Authors:Peschke, M., Haslinger, K., Cryle, M.J.
Deposit date:2014-07-02
Release date:2015-02-04
Modification date:2015-05-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis.
Nature, 521, 2015
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