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1FWX
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BU of 1fwx by Molmil
CRYSTAL STRUCTURE OF NITROUS OXIDE REDUCTASE FROM P. DENITRIFICANS
Descriptor: (MU-4-SULFIDO)-TETRA-NUCLEAR COPPER ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Brown, K, Djinovic-Carugo, K, Haltia, T, Cabrito, I, Saraste, M, Moura, J.J, Moura, I, Tegoni, M, Cambillau, C.
Deposit date:2000-09-25
Release date:2001-09-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Revisiting the Catalytic CuZ Cluster of Nitrous Oxide (N2O) Reductase. Evidence of a Bridging Inorganic Sulfur
J.Biol.Chem., 275, 2000
1HZU
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DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA
Descriptor: HEME C, HEME D, NITRITE REDUCTASE
Authors:Brown, K, Cutruzzola, F, Brunori, M, Tegoni, M, Cambillau, C.
Deposit date:2001-01-26
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
1HZV
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BU of 1hzv by Molmil
DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA
Descriptor: HEME C, HEME D, NITRIC OXIDE, ...
Authors:Brown, K, Tegoni, M, Cambillau, C.
Deposit date:2001-01-26
Release date:2001-09-26
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa.
J.Mol.Biol., 312, 2001
1CNO
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BU of 1cno by Molmil
STRUCTURE OF PSEUDOMONAS NAUTICA CYTOCHROME C552, BY MAD METHOD
Descriptor: CYTOCHROME C552, GLYCEROL, HEME C
Authors:Brown, K, Nurizzo, D, Cambillau, C.
Deposit date:1998-08-03
Release date:1999-07-22
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:MAD structure of Pseudomonas nautica dimeric cytochrome c552 mimicks the c4 Dihemic cytochrome domain association.
J.Mol.Biol., 289, 1999
1FWY
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BU of 1fwy by Molmil
CRYSTAL STRUCTURE OF N-ACETYLGLUCOSAMINE 1-PHOSPHATE URIDYLTRANSFERASE BOUND TO UDP-GLCNAC
Descriptor: 1,2-ETHANEDIOL, SULFATE ION, UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, ...
Authors:Brown, K, Pompeo, F, Dixon, S, Mengin-Lecreulx, D, Cambillau, C, Bourne, Y.
Deposit date:2000-09-25
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily.
EMBO J., 18, 1999
1FXJ
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BU of 1fxj by Molmil
CRYSTAL STRUCTURE OF N-ACETYLGLUCOSAMINE 1-PHOSPHATE URIDYLTRANSFERASE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE
Authors:Brown, K, Pompeo, F, Dixon, S, Mengin-Lecreulx, D, Cambillau, C, Bourne, Y.
Deposit date:2000-09-26
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily.
EMBO J., 18, 1999
1SM2
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BU of 1sm2 by Molmil
Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain
Descriptor: STAUROSPORINE, Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Long, J.M, Vial, S.C.M, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T.
Deposit date:2004-03-08
Release date:2004-07-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
J.Biol.Chem., 279, 2004
2EVA
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BU of 2eva by Molmil
Structural Basis for the Interaction of TAK1 Kinase with its Activating Protein TAB1
Descriptor: ADENOSINE, TAK1 kinase - TAB1 chimera fusion protein
Authors:Brown, K, Vial, S.C, Dedi, N, Long, J.M, Dunster, N.J, Cheetham, G.M.
Deposit date:2005-10-31
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the interaction of TAK1 kinase with its activating protein TAB1
J.Mol.Biol., 354, 2005
1SNX
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BU of 1snx by Molmil
CRYSTAL STRUCTURE OF APO INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN
Descriptor: Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T.
Deposit date:2004-03-12
Release date:2004-07-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
J.Biol.Chem., 279, 2004
1QNI
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BU of 1qni by Molmil
Crystal Structure of Nitrous Oxide Reductase from Pseudomonas nautica, at 2.4A Resolution
Descriptor: (MU-4-SULFIDO)-TETRA-NUCLEAR COPPER ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Brown, K, Tegoni, M, Cambillau, C.
Deposit date:1999-10-15
Release date:2000-10-13
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel type of catalytic copper cluster in nitrous oxide reductase.
Nat.Struct.Biol., 7, 2000
1SNU
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BU of 1snu by Molmil
CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN
Descriptor: STAUROSPORINE, Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T.
Deposit date:2004-03-12
Release date:2004-07-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
J.Biol.Chem., 279, 2004
1HZ0
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BU of 1hz0 by Molmil
NMR STRUCTURE OF THE 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE (PHIP) C8-DEOXYGUANOSINE ADDUCT IN DUPLEX DNA
Descriptor: 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE, DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3')
Authors:Brown, K, Cosman, M.
Deposit date:2001-01-23
Release date:2001-08-08
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA.
Proc.Natl.Acad.Sci.USA, 98, 2001
4B6L
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BU of 4b6l by Molmil
Discovery of Oral Polo-Like Kinase (PLK) Inhibitors with Enhanced Selectivity Profile using Residue Targeted Drug Design
Descriptor: 4-[[(4R)-5-cyclopentyl-4-ethyl-3a,4-dihydro-3H-[1,2,4]triazolo[4,3-f]pteridin-7-yl]amino]-N-cyclopropyl-3-methoxy-benzamide, SERINE/THREONINE-PROTEIN KINASE PLK3, SULFATE ION
Authors:Brown, K, Charrier, J.D, Durrant, S, Griffiths, M, Hudson, C, Kay, D, Knegtel, R, ODonnell, M, Pierard, F, Twin, H, Weber, P, Young, S.
Deposit date:2012-08-14
Release date:2013-08-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Oral Polo-Like Kinase (Plk) Inhibitors with Enhanced Selectivity Profile Using Residue Targeted Drug Design
To be Published
3S2U
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BU of 3s2u by Molmil
Crystal structure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex
Descriptor: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Brown, K, Vial, S.C.M, Dedi, N, Westcott, J, Scally, S, Bugg, T.D.H, Charlton, P.A, Cheetham, G.M.T.
Deposit date:2011-05-17
Release date:2012-09-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal Structure of the Pseudomonas aeruginosa MurG: UDP-GlcNAc Substrate Complex.
Protein Pept.Lett., 20, 2013
4DA5
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BU of 4da5 by Molmil
Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology
Descriptor: (3R)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol, Choline kinase alpha, SULFATE ION
Authors:Brown, K, Hudson, C, Charlton, P, Pollard, J.
Deposit date:2012-01-12
Release date:2013-04-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Kinetic and mechanistic characterisation of Choline Kinase-alpha.
Biochim.Biophys.Acta, 1834, 2013
3QGW
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BU of 3qgw by Molmil
Crystal Structure of ITK kinase bound to an inhibitor
Descriptor: 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide, N-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide, Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Cheetham, G.M.T.
Deposit date:2011-01-25
Release date:2011-06-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors
J.Med.Chem., 54, 2011
3QGY
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BU of 3qgy by Molmil
Crystal structure of ITK inhibitor complex
Descriptor: 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide, N-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide, Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Cheetham, G.M.T.
Deposit date:2011-01-25
Release date:2011-06-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors
J.Med.Chem., 54, 2011
7NBV
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BU of 7nbv by Molmil
Structure of 2A protein from Theilers murine encephalomyelitis virus (TMEV)
Descriptor: BROMIDE ION, Capsid protein VP0
Authors:Hill, C.H, Cook, G.M, Napthine, S, Kibe, A, Brown, K, Caliskan, N, Firth, A.E, Graham, S.C, Brierley, I.
Deposit date:2021-01-28
Release date:2021-12-08
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus.
Nucleic Acids Res., 49, 2021
4QC8
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Structural annotation of pathogenic bovine Parvovirus-1
Descriptor: VP2
Authors:Kailasan, S, Halder, S, Gurda, B.L, Bladek, H, Chipman, P.R, McKenna, R, Brown, K, Agbandje-McKenna, M.
Deposit date:2014-05-09
Release date:2015-01-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of an enteric pathogen, bovine parvovirus.
J.Virol., 89, 2015
1CRZ
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BU of 1crz by Molmil
CRYSTAL STRUCTURE OF THE E. COLI TOLB PROTEIN
Descriptor: TOLB PROTEIN
Authors:Abergel, C, Bouveret, E, Claverie, J.-M, Brown, K, Rigal, A, Lazdunski, C, Benedetti, H.
Deposit date:1999-08-16
Release date:2000-08-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.
Structure Fold.Des., 7, 1999
1E5P
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BU of 1e5p by Molmil
Crystal structure of aphrodisin, a sex pheromone from female hamster
Descriptor: APHRODISIN
Authors:Vincent, F, Brown, K, Spinelli, S, Cambillau, C, Tegoni, M.
Deposit date:2000-07-28
Release date:2001-07-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal structure of aphrodisin, a sex pheromone from female hamster.
J.Mol.Biol., 305, 2001
1GJQ
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BU of 1gjq by Molmil
Pseudomonas aeruginosa cd1 nitrite reductase reduced cyanide complex
Descriptor: CYANIDE ION, HEME C, HEME D, ...
Authors:Nurizzo, D, Brown, K, Tegoni, M, Cambillau, C.
Deposit date:2001-08-01
Release date:2002-08-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cyanide Binding to Cd(1) Nitrite Reductase from Pseudomonas Aeruginosa: Role of the Active-Site His369 in Ligand Stabilization.
Biochem.Biophys.Res.Commun., 291, 2002
1QD0
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BU of 1qd0 by Molmil
CAMELID HEAVY CHAIN VARIABLE DOMAINS PROVIDE EFFICIENT COMBINING SITES TO HAPTENS
Descriptor: 3-HYDROXY-7-(4-{1-[2-HYDROXY-3-(2-HYDROXY-5-SULFO-PHENYLAZO)-BENZYL]-2-SULFO-ETHYLAMINO}-[1,2,5]TRIAZIN-2-YLAMINO)-2-(2-HYDROXY-5-SULFO-PHENYLAZO)-NAPTHALENE-1,8-DISULFONIC ACID, COPPER (II) ION, VHH-R2 ANTI-RR6 ANTIBODY
Authors:Spinelli, S, Frenken, L.G.J, Hermans, P, Verrips, T, Brown, K, Tegoni, M, Cambillau, C.
Deposit date:1999-07-08
Release date:2000-07-19
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Camelid heavy-chain variable domains provide efficient combining sites to haptens.
Biochemistry, 39, 2000
5CCP
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BU of 5ccp by Molmil
HISTIDINE 52 IS A CRITICAL RESIDUE FOR RAPID FORMATION OF CYTOCHROME C PEROXIDASE COMPOUND I
Descriptor: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Brown, K, Shaw, A, Miller, M.A, Kraut, J.
Deposit date:1993-06-07
Release date:1993-10-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Histidine 52 is a critical residue for rapid formation of cytochrome c peroxidase compound I.
Biochemistry, 32, 1993
5URF
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BU of 5urf by Molmil
The structure of human bocavirus 1
Descriptor: viral protein 3
Authors:Mietzsch, M, Kailasan, S, Garrison, J, Ilyas, M, Chipman, P, Kandola, K, Jansen, M, Spear, J, Sousa, D, McKenna, R, Soderlund-Venermo, M, Baker, T, Agbandje-McKenna, M.
Deposit date:2017-02-10
Release date:2017-03-29
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017

 

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