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2GX9
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BU of 2gx9 by Molmil
X-ray structure of influenza virus NS1 effector domain
Descriptor: NS1 Effector Domain, THIOCYANATE ION
Authors:Bornholdt, Z.A, Prasad, B.V.
Deposit date:2006-05-08
Release date:2006-05-30
Last modified:2020-09-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray structure of influenza virus NS1 effector domain.
Nat.Struct.Mol.Biol., 13, 2006
5HJ3
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BU of 5hj3 by Molmil
Crystal structure of host-primed Ebola virus GP, GPcl.
Descriptor: Envelope glycoprotein, KZ52 Antibody Fragment, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bornholdt, Z.A, Fusco, M.L, Saphire, E.O.
Deposit date:2016-01-12
Release date:2016-03-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
Mbio, 7, 2016
3F5T
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BU of 3f5t by Molmil
X-ray Structure of H5N1 NS1
Descriptor: Nonstructural protein 1
Authors:Bornholdt, Z.A, Prasad, B.V.V.
Deposit date:2008-11-04
Release date:2008-11-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus
Nature, 456, 2008
4LDD
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BU of 4ldd by Molmil
Crystal Structure of Ebola virus VP40 Hexamer
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.498 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDM
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BU of 4ldm by Molmil
Crystal Structure of an RNA-free VP40 Octameric Ring
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDI
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BU of 4ldi by Molmil
Low resolution structure of Ebola virus M241R mutant
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.15 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LDB
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BU of 4ldb by Molmil
Crystal Structure of Ebola Virus VP40 Dimer
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
4LD8
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BU of 4ld8 by Molmil
Crystal Structure of Dimeric Sudan Virus VP40
Descriptor: Matrix protein VP40
Authors:Bornholdt, Z.A, Ableson, D.M, Saphire, E.O.
Deposit date:2013-06-24
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle.
Cell(Cambridge,Mass.), 154, 2013
5B0V
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BU of 5b0v by Molmil
Crystal Structure of Marburg virus VP40 Dimer
Descriptor: ETHANOL, Matrix protein VP40
Authors:Oda, S, Bornholdt, Z.A, Abelson, D.M, Saphire, E.O.
Deposit date:2015-11-05
Release date:2016-01-20
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression
J.Virol., 90, 2015
3KS4
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BU of 3ks4 by Molmil
Crystal structure of Reston ebolavirus VP35 RNA binding domain
Descriptor: Polymerase cofactor VP35
Authors:Kimberlin, C.R, Bornholdt, Z.A, Li, S, Woods, V.L, Macrae, I.J, Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
3KS8
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BU of 3ks8 by Molmil
Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA
Descriptor: 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35
Authors:Kimberlin, C.R, Bornholdt, Z.A, Li, S, Woods, V.L, Macrae, I.J, Saphire, E.O.
Deposit date:2009-11-20
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Proc.Natl.Acad.Sci.USA, 107, 2009
7JZJ
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BU of 7jzj by Molmil
Crystal structure demonstrating CTD-CTD interactions of Zaire Ebola virus VP40 dimer
Descriptor: Matrix protein VP40, PENTAETHYLENE GLYCOL
Authors:Norris, M.J, Bornholdt, Z.A, Saphire, E.O.
Deposit date:2020-09-02
Release date:2020-10-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers.
Elife, 9, 2020
7JZT
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BU of 7jzt by Molmil
Low resolution crystal structure of Zaire Ebola virus VP40 in space group P6422
Descriptor: Matrix protein VP40
Authors:Norris, M.J, Bornholdt, Z.A, Saphire, E.O.
Deposit date:2020-09-02
Release date:2020-10-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers.
Elife, 9, 2020
4GHA
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BU of 4gha by Molmil
Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA
Descriptor: Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3')
Authors:Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
4GH9
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BU of 4gh9 by Molmil
Crystal structure of Marburg virus VP35 RNA binding domain
Descriptor: ACETATE ION, Polymerase cofactor VP35
Authors:Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O.
Deposit date:2012-08-07
Release date:2012-08-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Plos Pathog., 8, 2012
4LG2
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BU of 4lg2 by Molmil
Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA
Descriptor: Polymerase cofactor, dsRNA
Authors:Bale, S, Julien, J.-P, Bornholdt, Z.A, Krois, A.S, Wilson, I.A, Saphire, E.O.
Deposit date:2013-06-27
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism.
J.Virol., 87, 2013
4N5B
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BU of 4n5b by Molmil
Crystal structure of the Nipah virus phosphoprotein tetramerization domain
Descriptor: IMIDAZOLE, Phosphoprotein
Authors:Bruhn, J.F, Barnett, K, Bibby, J, Thomas, J, Keegan, R, Rigden, D, Bornholdt, Z.A, Saphire, E.O.
Deposit date:2013-10-09
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the nipah virus phosphoprotein tetramerization domain.
J.Virol., 88, 2014
4OPH
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BU of 4oph by Molmil
X-ray structure of full-length H6N6 NS1
Descriptor: Nonstructural protein 1
Authors:Carrillo, B, Choi, J.M, Bornholdt, Z.A, Sankaran, S, Rice, A.P, Prasad, B.V.V.
Deposit date:2014-02-05
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.158 Å)
Cite:The Influenza A Virus Protein NS1 Displays Structural Polymorphism.
J.Virol., 88, 2014
4D9O
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BU of 4d9o by Molmil
Structure of ebolavirus protein VP24 from Reston
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P.
Deposit date:2012-01-11
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
Plos Pathog., 8, 2012
5UQY
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BU of 5uqy by Molmil
Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ...
Authors:Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O.
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
3VNE
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BU of 3vne by Molmil
Structure of the ebolavirus protein VP24 from Sudan
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P.
Deposit date:2012-01-12
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
Plos Pathog., 8, 2012
3VNF
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BU of 3vnf by Molmil
Structure of the ebolavirus protein VP24 from Sudan
Descriptor: Membrane-associated protein VP24
Authors:Zhang, A.P.P.
Deposit date:2012-01-12
Release date:2012-04-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold
Plos Pathog., 8, 2012
7A59
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BU of 7a59 by Molmil
Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Orthorhombic Crystal Form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Envelopment polyprotein, ...
Authors:Hellert, J, Guardado-Calvo, P, Rey, F.A.
Deposit date:2020-08-20
Release date:2021-10-06
Last modified:2022-04-20
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.
Science, 375, 2022
7A5A
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BU of 7a5a by Molmil
Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Monoclinic Crystal Form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Envelopment polyprotein
Authors:Hellert, J, Guardado-Calvo, P, Rey, F.A.
Deposit date:2020-08-20
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.
Science, 375, 2022
7KI6
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BU of 7ki6 by Molmil
Structure of the HeV F glycoprotein in complex with the 1F5 neutralizing antibody
Descriptor: 1F5 Fab light chain, 1F5 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dang, H.V, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:2020-10-23
Release date:2021-05-05
Last modified:2021-06-23
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins.
Nat.Struct.Mol.Biol., 28, 2021

 

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