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3PHX
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BU of 3phx by Molmil
OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with ISG15
Descriptor: ACETIC ACID, ETHANAMINE, RNA-directed RNA polymerase L, ...
Authors:Akutsu, M, Ye, Y, Virdee, S, Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PHU
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BU of 3phu by Molmil
OTU Domain of Crimean Congo Hemorrhagic Fever Virus
Descriptor: GLYCEROL, RNA-directed RNA polymerase L
Authors:Akutsu, M, Ye, Y, Virdee, S, Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PHW
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BU of 3phw by Molmil
OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin
Descriptor: ETHANAMINE, RNA-directed RNA polymerase L, Ubiquitin-40S ribosomal protein S27a
Authors:Akutsu, M, Ye, Y, Virdee, S, Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
1WRD
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BU of 1wrd by Molmil
Crystal structure of Tom1 GAT domain in complex with ubiquitin
Descriptor: Target of Myb protein 1, Ubiquitin
Authors:Akutsu, M, Kawasaki, M, Katoh, Y, Shiba, T, Yamaguchi, Y, Kato, R, Kato, K, Nakayama, K, Wakatsuki, S.
Deposit date:2004-10-14
Release date:2005-10-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain.
Febs Lett., 579, 2005
6XX0
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BU of 6xx0 by Molmil
Crystal structure of NEMO in complex with Ubv-LIN
Descriptor: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b, ...
Authors:Akutsu, M, Skenderovic, A, Garcia-Pardo, J, Maculins, T, Dikic, I.
Deposit date:2020-01-26
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
6EIH
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BU of 6eih by Molmil
The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide
Descriptor: 14-3-3 protein epsilon, SER-ILE-SEP-ARG
Authors:Akutsu, M, Wagner, S.A, Beli, P.
Deposit date:2017-09-19
Release date:2018-02-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.
Nat Commun, 9, 2018
4P09
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BU of 4p09 by Molmil
Crystal structure of HOIP PUB domain
Descriptor: E3 ubiquitin-protein ligase RNF31
Authors:Akutsu, M, Schaeffer, V, Olma, M.H, Gomes, L.C, Kawasaki, M, Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4P0A
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BU of 4p0a by Molmil
Crystal structure of HOIP PUB domain in complex with p97 PIM
Descriptor: E3 ubiquitin-protein ligase RNF31, Transitional endoplasmic reticulum ATPase
Authors:Akutsu, M, Schaeffer, V, Olma, M.H, Gomes, L.C, Kawasaki, M, Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3001 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4P0B
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BU of 4p0b by Molmil
Crystal structure of HOIP PUB domain in complex with OTULIN PIM
Descriptor: E3 ubiquitin-protein ligase RNF31, Ubiquitin thioesterase otulin
Authors:Akutsu, M, Schaeffer, V, Olma, M.H, Gomes, L.C, Kawasaki, M, Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7005 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
3VVV
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BU of 3vvv by Molmil
Skich domain of NDP52
Descriptor: Calcium-binding and coiled-coil domain-containing protein 2
Authors:Akutsu, M, Muhlinen, N.V, Randow, F, Komander, D.
Deposit date:2012-07-28
Release date:2013-02-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Mol.Cell, 48, 2012
3VVW
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BU of 3vvw by Molmil
NDP52 in complex with LC3C
Descriptor: Calcium-binding and coiled-coil domain-containing protein 2, Microtubule-associated proteins 1A/1B light chain 3C
Authors:Akutsu, M, Muhlinen, N.V, Randow, F, Komander, D.
Deposit date:2012-07-28
Release date:2013-02-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy
Mol.Cell, 48, 2012
2ZFY
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BU of 2zfy by Molmil
Crystal structure of human Otubain 1
Descriptor: Ubiquitin thioesterase OTUB1
Authors:Akutsu, M, Walker, J.R, Li, Y, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-01-16
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural basis and specificity of human otubain 1-mediated deubiquitination.
Biochem.J., 418, 2009
7NCY
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BU of 7ncy by Molmil
Dual specificity phosphatase from Sulfolobales Beppu filamentous virus 3
Descriptor: Dual specificity phosphatase, GLYCEROL, NICKEL (II) ION
Authors:Welin, M, Akutsu, M, Hakansson, M, Al-Karadaghi, S, Jasilionis, A, Nordberg Karlsson, E.
Deposit date:2021-01-29
Release date:2022-03-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dual specificity phosphatase from Sulfolobales Beppu filamentous virus 3
To Be Published
5HKH
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BU of 5hkh by Molmil
Crystal structure of Ufm1 in complex with UBA5
Descriptor: ASP-ASN-GLU-TRP-GLY-ILE-GLU-LEU-VAL, Ubiquitin-fold modifier 1
Authors:Huber, J, Doetsch, V, Rogov, V.V, Akutsu, M.
Deposit date:2016-01-14
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation.
J.Biol.Chem., 291, 2016
6YEK
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BU of 6yek by Molmil
Crystal structure of human NEMO apo form
Descriptor: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b
Authors:Garcia-Pardo, J, Akutsu, M, Busse, P, Skenderovic, A, Maculins, T, Dikic, I.
Deposit date:2020-03-25
Release date:2021-03-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
7TPS
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BU of 7tps by Molmil
Crystal structure of ALPN-202 (engineered CD80 vIgD) in complex with PD-L1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Demonte, D.W, Maurer, M.F, Akutsu, M, Kimbung, Y.R, Logan, D.T, Walse, B.
Deposit date:2022-01-26
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Nat Commun, 13, 2022
4ZDV
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BU of 4zdv by Molmil
Crystal structure of LC3 in complex with FAM134B LIR
Descriptor: Microtubule-associated proteins 1A/1B light chain 3A
Authors:Khaminets, A, Grumati, P, Dikic, I, Akutsu, M.
Deposit date:2015-04-19
Release date:2015-06-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Regulation of endoplasmic reticulum turnover by selective autophagy.
Nature, 522, 2015
8IMD
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BU of 8imd by Molmil
Crystal structure of Cu/Zn Superoxide dismutase from Paenibacillus lautus
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COPPER (II) ION, Cu/Zn-Superoxide dismutase, ...
Authors:Narikiyo, S, Furukawa, Y, Akutsu, M.
Deposit date:2023-03-06
Release date:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of a novel cysteine-less Cu/Zn-superoxide dismutase in Paenibacillus lautus missing a conserved disulfide bond.
J.Biol.Chem., 299, 2023
6HB9
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BU of 6hb9 by Molmil
Crystal structure of the GABARAP in complex with the UBA5 LIR motif
Descriptor: Gamma-aminobutyric acid receptor-associated protein
Authors:Huber, J, Rogov, V, Akutsu, M.
Deposit date:2018-08-10
Release date:2019-05-01
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy, 16, 2020
6H8C
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BU of 6h8c by Molmil
Structure of the human GABARAPL2 protein in complex with the UBA5 LIR motif
Descriptor: Gamma-aminobutyric acid receptor-associated protein-like 2, Ubiquitin-like modifier-activating enzyme 5
Authors:Huber, J, Loehr, F, Gruber, J, Akutsu, M, Guentert, P, Doetsch, V, Rogov, V.V.
Deposit date:2018-08-02
Release date:2019-05-01
Last modified:2020-01-29
Method:SOLUTION NMR
Cite:An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy, 16, 2020
5DCN
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BU of 5dcn by Molmil
Crystal structure of LC3 in complex with TECPR2 LIR
Descriptor: Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION
Authors:Stadel, D, Huber, J, Dotsch, V, Rogov, V.V, Behrends, C, Akutsu, M.
Deposit date:2015-08-24
Release date:2016-03-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export.
Mol.Cell, 60, 2015
4XC2
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BU of 4xc2 by Molmil
Crystal structure of GABARAP in complex with KBTBD6 LIR peptide
Descriptor: GABA(A) receptor-associated protein, Kelch repeat and BTB domain-containing protein 6
Authors:Huber, J, Genau, H.M, Baschieri, F, Doetsch, V, Farhan, H, Rogov, V.V, Behrends, C, Akutsu, M.
Deposit date:2014-12-17
Release date:2015-03-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling.
Mol.Cell, 57, 2015
5LRV
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BU of 5lrv by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin
Descriptor: GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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BU of 5lrw by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin
Descriptor: GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRX
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BU of 5lrx by Molmil
Structure of A20 OTU domain bound to ubiquitin
Descriptor: Polyubiquitin-B, Tumor necrosis factor alpha-induced protein 3
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016

 

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