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3SE7
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BU of 3se7 by Molmil
ancient VanA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, VanA
Authors:Wright, G.D, Morar, M.
Deposit date:2011-06-10
Release date:2011-09-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Antibiotic resistance is ancient.
Nature, 477, 2011
4WQK
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BU of 4wqk by Molmil
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, apo form
Descriptor: 2''-aminoglycoside nucleotidyltransferase, CHLORIDE ION, GLYCEROL, ...
Authors:Cox, G, Stogios, P.J, Savchenko, A, Wright, G.D, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-10-22
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.482 Å)
Cite:Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Mbio, 6, 2015
4WQL
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BU of 4wql by Molmil
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, kanamycin-bound
Descriptor: 2''-aminoglycoside nucleotidyltransferase, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Cox, G, Stogios, P.J, Savchenko, A, Wright, G.D, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-10-22
Release date:2014-11-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Mbio, 6, 2015
6BRD
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BU of 6brd by Molmil
Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Cox, G, Kelso, J, Stogios, P.J, Savchenko, A, Anderson, W.F, Wright, G.D, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-11-30
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
Cell Chem Biol, 25, 2018
2XDO
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BU of 2xdo by Molmil
Structure of the Tetracycline degrading Monooxygenase TetX2 from Bacteroides thetaiotaomicron
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TETX2 PROTEIN
Authors:Volkers, G, Palm, G.J, Wright, G.D, Hinrichs, W.
Deposit date:2010-05-05
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.
FEBS Lett., 585, 2011
8UK6
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BU of 8uk6 by Molmil
Candida albicans glutaminyl tRNA synthetase (GLN4) in complex with N-pyrimidinyl-beta-thiophenylacrylamide
Descriptor: (2E)-N-(pyrimidin-2-yl)-3-(thiophen-2-yl)prop-2-enamide, ZINC ION, glutamine--tRNA ligase
Authors:Sychantha, D, Wright, G.D.
Deposit date:2023-10-12
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-beta-thiophenylacrylamides exerts highly selective antifungal activity.
Cell Chem Biol, 2024
7UUN
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BU of 7uun by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with neomycin
Descriptor: 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, NEOMYCIN
Authors:Stogios, P.J, Evdokimova, E, Di Leo, R, Osipiuk, J, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-04-28
Release date:2022-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUL
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BU of 7uul by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with kanamycin B and coenzyme A
Descriptor: (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ...
Authors:Stogios, P.J, Evdokimova, E, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-04-28
Release date:2022-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUM
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BU of 7uum by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with paromomycin and coenzyme A
Descriptor: Aminocyclitol acetyltransferase ApmA, COENZYME A, GLYCEROL, ...
Authors:Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-04-28
Release date:2022-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUO
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BU of 7uuo by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A
Descriptor: 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, COENZYME A, ...
Authors:Stogios, P.J, Evdokimova, E, Michalska, K, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-04-28
Release date:2022-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUK
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BU of 7uuk by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with tobramycin
Descriptor: Aminocyclitol acetyltransferase ApmA, CHLORIDE ION, TOBRAMYCIN
Authors:Stogios, P.J, Evdokimova, E, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2022-04-28
Release date:2023-04-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
2Y6Q
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BU of 2y6q by Molmil
Structure of the TetX monooxygenase in complex with the substrate 7- Iodtetracycline
Descriptor: 7-IODOTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
Authors:Volkers, G, Palm, G.J, Weiss, M.S, Wright, G.D, Hinrichs, W.
Deposit date:2011-01-25
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.
FEBS Lett., 585, 2011
2Y6R
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BU of 2y6r by Molmil
Structure of the TetX monooxygenase in complex with the substrate 7- chlortetracycline
Descriptor: 7-CHLOROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
Authors:Volkers, G, Palm, G.J, Weiss, M.S, Wright, G.D, Hinrichs, W.
Deposit date:2011-01-25
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.
FEBS Lett., 585, 2011
3TYK
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BU of 3tyk by Molmil
Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia
Descriptor: CHLORIDE ION, HYGROMYCIN B VARIANT, Hygromycin-B 4-O-kinase
Authors:Stogios, P.J, Shabalin, I.G, Shakya, T, Evdokmova, E, Fan, Y, Chruszcz, M, Minor, W, Wright, G.D, Savchenko, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-09-26
Release date:2011-10-12
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.
J.Biol.Chem., 286, 2011
3JZ0
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BU of 3jz0 by Molmil
LinB complexed with clindamycin and AMPCPP
Descriptor: CLINDAMYCIN, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Lincosamide nucleotidyltransferase, ...
Authors:Morar, M, Wright, G.D.
Deposit date:2009-09-22
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB.
Structure, 17, 2009
3JYY
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BU of 3jyy by Molmil
SeMet LinB complexed with PPi
Descriptor: Lincosamide nucleotidyltransferase, MAGNESIUM ION, PYROPHOSPHATE
Authors:Morar, M, Wright, G.D.
Deposit date:2009-09-22
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB.
Structure, 17, 2009
4DFU
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BU of 4dfu by Molmil
Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA in complex with kanamycin inhibited with quercetin
Descriptor: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, APH(2")-Id, CHLORIDE ION, ...
Authors:Stogios, P.J, Minasov, G, Dong, A, Evdokimova, E, Egorova, E, Di Leo, R, Li, H, Shakya, T, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-24
Release date:2012-02-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A small molecule discrimination map of the antibiotic resistance kinome.
Chem.Biol., 18, 2011
4DBX
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BU of 4dbx by Molmil
Crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA
Descriptor: APH(2")-ID
Authors:Stogios, P.J, Minasov, G, Tan, K, Nocek, B, Singer, A.U, Evdokimova, E, Egorova, E, Di Leo, R, Li, H, Shakya, T, Wright, G.D, Savchenko, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG)
Deposit date:2012-01-16
Release date:2012-02-01
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:A small molecule discrimination map of the antibiotic resistance kinome.
Chem.Biol., 18, 2011
4EJ7
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BU of 4ej7 by Molmil
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Aminoglycoside 3'-phosphotransferase AphA1-IAB, CALCIUM ION, ...
Authors:Stogios, P.J, Minasov, G, Tan, K, Evdokimova, E, Egorova, O, Di Leo, R, Shakya, T, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-06
Release date:2012-04-18
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
3DHO
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BU of 3dho by Molmil
Structure of Streptogramin Acetyltransferase in Complex with an Inhibitor
Descriptor: 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide, DIMETHYL SULFOXIDE, FORMIC ACID, ...
Authors:Roderick, S.L, Pesaresi, A, Wright, G.D.
Deposit date:2008-06-18
Release date:2009-09-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Streptogramin Acetyltransferase in Complex with an Inhibitor
To be Published
1EBU
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BU of 1ebu by Molmil
HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE
Descriptor: 3-AMINOMETHYL-PYRIDINIUM-ADENINE-DINUCLEOTIDE, HOMOSERINE DEHYDROGENASE, L-HOMOSERINE, ...
Authors:DeLaBarre, B, Thompson, P.R, Wright, G.D, Berghuis, A.M.
Deposit date:2000-01-24
Release date:2000-03-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
Nat.Struct.Biol., 7, 2000
1EBF
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BU of 1ebf by Molmil
HOMOSERINE DEHYDROGENASE FROM S. CEREVISIAE COMPLEX WITH NAD+
Descriptor: HOMOSERINE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION
Authors:DeLaBarre, B, Thompson, P.R, Wright, G.D, Berghuis, A.M.
Deposit date:2000-01-24
Release date:2000-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
Nat.Struct.Biol., 7, 2000
4FEV
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BU of 4fev by Molmil
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1
Descriptor: 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, ACETATE ION, Aminoglycoside 3'-phosphotransferase AphA1-IAB, ...
Authors:Stogios, P.J, Evdokimova, E, Wawrzak, Z, Minasov, G, Egorova, O, Di Leo, R, Shakya, T, Spanogiannopoulos, P, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4FEU
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BU of 4feu by Molmil
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125
Descriptor: 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, ACETATE ION, Aminoglycoside 3'-phosphotransferase AphA1-IAB, ...
Authors:Stogios, P.J, Evdokimova, E, Wawrzak, Z, Minasov, G, Egorova, O, Di Leo, R, Shakya, T, Spanogiannopoulos, P, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4FEW
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BU of 4few by Molmil
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2
Descriptor: 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, ACETATE ION, Aminoglycoside 3'-phosphotransferase AphA1-IAB, ...
Authors:Stogios, P.J, Evdokimova, E, Wawrzak, Z, Minasov, G, Egorova, O, Di Leo, R, Shakya, T, Spanogiannopoulos, P, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013

217705

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