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3KTU
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BU of 3ktu by Molmil
Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA
Descriptor: CALCIUM ION, DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*AP*(FDG)P*GP*TP*CP*TP*AP*C)-3'), ...
Authors:Verdine, G.L, Lee, S.M.
Deposit date:2009-11-26
Release date:2010-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural investigation of hOGG1 bound to a fluorinated oxoG analog
to be published
3IH7
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BU of 3ih7 by Molmil
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
Descriptor: 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3', N-glycosylase/DNA lyase
Authors:Verdine, G.L, Crenshaw, C.M, Oo, K.S, Kutchukian, P.S.
Deposit date:2009-07-29
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1
To be Published
3UBT
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BU of 3ubt by Molmil
Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA
Descriptor: 5'-D(*TP*GP*GP*CP*CP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Verdine, G.L, Didovyk, A.
Deposit date:2011-10-24
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structural origins of DNA target selection and nucleobase extrusion by a DNA Cytosine methyltransferase.
J.Biol.Chem., 287, 2012
3C65
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BU of 3c65 by Molmil
Crystal Structure of Bacillus stearothermophilus UvrC 5' endonuclease domain
Descriptor: UvrABC system protein C
Authors:Pakotiprapha, D, Bowman, B.R, Mueller, A.A, Inuzuka, Y, Verdine, G.L.
Deposit date:2008-02-02
Release date:2008-08-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Bacillus stearothermophilus UvrC 5' endonuclease domain
To be Published
4DJS
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BU of 4djs by Molmil
Structure of beta-catenin in complex with a stapled peptide inhibitor
Descriptor: Catenin beta-1, stapled peptide RRWPQ(MK8)ILD(MK8)HVRRVWR
Authors:Bowman, B.R, Grossmann, T.N, Yeh, J.T.-H, Verdine, G.L.
Deposit date:2012-02-02
Release date:2012-10-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.029 Å)
Cite:Inhibition of oncogenic Wnt signaling through direct targeting of beta-catenin.
Proc.Natl.Acad.Sci.USA, 109, 2012
5KN9
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BU of 5kn9 by Molmil
MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair
Descriptor: Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ...
Authors:Wang, L, Chakravarthy, S, Verdine, G.L.
Deposit date:2016-06-27
Release date:2017-02-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase.
J. Biol. Chem., 292, 2017
5KN8
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BU of 5kn8 by Molmil
MutY N-terminal domain in complex with undamaged DNA
Descriptor: Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ...
Authors:Wang, L, Chakravarthy, S, Verdine, G.L.
Deposit date:2016-06-27
Release date:2017-02-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase.
J. Biol. Chem., 292, 2017
6O8E
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BU of 6o8e by Molmil
Crystal structure of UvrB bound to duplex DNA with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*GP*CP*CP*GP*TP*AP*TP*GP*CP*CP*AP*AP*TP*CP*TP*AP*GP*AP*GP*C)-3'), ...
Authors:Lee, S.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6O8G
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BU of 6o8g by Molmil
Crystal structure of UvrB bound to fully duplex DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*CP*GP*AP*TP*GP*GP*AP*GP*A)-3'), ...
Authors:Lee, S.-J, Sung, R.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6O8H
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BU of 6o8h by Molmil
Crystal structure of UvrB mutant bound to duplex DNA
Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*GP*CP*GP*CP*GP*AP*TP*GP*GP*AP*GP*A)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*GP*CP*GP*CP*TP*AP*CP*C)-3'), ...
Authors:Lee, S.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6O8F
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BU of 6o8f by Molmil
Crystal structure of UvrB bound to duplex DNA
Descriptor: ACETATE ION, CHLORIDE ION, DNA (5'-D(*GP*CP*CP*GP*TP*AP*TP*GP*CP*CP*AP*AP*TP*CP*TP*AP*GP*AP*GP*C)-3'), ...
Authors:Lee, S.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6OQA
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BU of 6oqa by Molmil
Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product
Descriptor: (3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ...
Authors:Lee, S.-J, Shigdel, U.K, Townson, S.A, Verdine, G.L.
Deposit date:2019-04-26
Release date:2020-04-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.
Proc.Natl.Acad.Sci.USA, 117, 2020
1ADN
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BU of 1adn by Molmil
SOLUTION STRUCTURE OF THE DNA METHYLPHOSPHOTRIESTER REPAIR DOMAIN OF ESCHERICHIA COLI ADA
Descriptor: N-ADA 10, ZINC ION
Authors:Myers, L.C, Verdine, G.L, Wagner, G.
Deposit date:1993-09-30
Release date:1994-01-31
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of the DNA methyl phosphotriester repair domain of Escherichia coli Ada.
Biochemistry, 32, 1993
2R6F
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BU of 2r6f by Molmil
Crystal Structure of Bacillus stearothermophilus UvrA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Excinuclease ABC subunit A, ZINC ION
Authors:Inuzuka, Y, Pakotiprapha, D, Bowman, B.R, Jeruzalmi, D, Verdine, G.L.
Deposit date:2007-09-05
Release date:2008-01-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of Bacillus stearothermophilus UvrA Provides Insight into ATP-Modulated Dimerization, UvrB Interaction, and DNA Binding.
Mol.Cell, 29, 2008
4YPR
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BU of 4ypr by Molmil
Crystal Structure of D144N MutY bound to its anti-substrate
Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ...
Authors:Wang, L, Lee, S, Verdine, G.L.
Deposit date:2015-03-13
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.
J.Biol.Chem., 290, 2015
4YOQ
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BU of 4yoq by Molmil
Crystal Structure of MutY bound to its anti-substrate
Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ...
Authors:Wang, L, Lee, S, Verdine, G.L.
Deposit date:2015-03-11
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.
J.Biol.Chem., 290, 2015
4YPH
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BU of 4yph by Molmil
Crystal Structure of MutY bound to its anti-substrate with the disulfide cross-linker reduced
Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(TP*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ...
Authors:Wang, L, Lee, S, Verdine, G.L.
Deposit date:2015-03-12
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.
J.Biol.Chem., 290, 2015
4G4O
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BU of 4g4o by Molmil
MutM containing M77A mutation bound to oxoG-containing DNA
Descriptor: DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(8OG)P*AP*GP*(TX2)P*CP*TP*AP*CP*C)-3'), DNA (5'-D(P*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L.
Deposit date:2012-07-16
Release date:2013-02-20
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM.
J.Biol.Chem., 288, 2013
4G4R
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BU of 4g4r by Molmil
MutM containing F114A mutation bound to oxoG-containing DNA
Descriptor: DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(8OG)P*AP*GP*(TX2)P*CP*TP*AP*CP*C)-3'), DNA (5'-D(P*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L.
Deposit date:2012-07-16
Release date:2013-02-20
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM.
J.Biol.Chem., 288, 2013
4G4N
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BU of 4g4n by Molmil
MutM containing M77A mutation bound to undamaged DNA
Descriptor: DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*AP*GP*(TX2)P*CP*TP*AP*CP*C)-3'), DNA (5'-D(P*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L.
Deposit date:2012-07-16
Release date:2013-02-20
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM.
J.Biol.Chem., 288, 2013
4G4Q
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BU of 4g4q by Molmil
MutM containing F114A mutation bound to undamaged DNA
Descriptor: DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*GP*AP*GP*(TX2)P*CP*TP*AP*CP*C)-3'), Formamidopyrimidine-DNA glycosylase, ...
Authors:Sung, R.J, Zhang, M, Qi, Y, Verdine, G.L.
Deposit date:2012-07-16
Release date:2013-02-20
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM.
J.Biol.Chem., 288, 2013
3JR4
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BU of 3jr4 by Molmil
MutM interrogating an extrahelical G
Descriptor: DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*G*CP*GP*TP*CP*CP*AP*(GX1)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ...
Authors:Qi, Y, Spong, M.C, Verdine, G.L.
Deposit date:2009-09-08
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM.
J.Biol.Chem., 285, 2010
3JR5
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BU of 3jr5 by Molmil
MutM lesion recognition control complex with N174C crosslinking site
Descriptor: DNA (5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*CP*CP*(OGX)P*AP*GP*TP*CP*TP*AP*CP*C)-3'), DNA glycosylase, ...
Authors:Qi, Y, Spong, M.C, Verdine, G.L.
Deposit date:2009-09-08
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.704 Å)
Cite:Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM.
J.Biol.Chem., 285, 2010
1DCT
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BU of 1dct by Molmil
DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA
Descriptor: CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ...
Authors:Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N.
Deposit date:1995-05-17
Release date:1995-09-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.
Cell(Cambridge,Mass.), 82, 1995
1FN7
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BU of 1fn7 by Molmil
COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
Descriptor: 8-OXOGUANINE DNA GLYCOSYLASE 1, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), ...
Authors:Norman, D.P.G, Bruner, S.D, Verdine, G.L.
Deposit date:2000-08-21
Release date:2001-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
J.Am.Chem.Soc., 123, 2001

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