1I5N
 
 | | Crystal structure of the P1 domain of CheA from Salmonella typhimurium | | Descriptor: | CHEMOTAXIS PROTEIN CHEA, SULFATE ION | | Authors: | Mourey, L, Da Re, S, Pedelacq, J.-D, Tolstyk, T, Faurie, C, Guillet, V, Stock, J.B, Samama, J.-P. | | Deposit date: | 2001-02-28 | | Release date: | 2001-07-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Crystal structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis
J.Biol.Chem., 276, 2001
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1ATT
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1AVB
 | | ARCELIN-1 FROM PHASEOLUS VULGARIS L | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARCELIN-1, ... | | Authors: | Mourey, L, Pedelacq, J.D, Fabre, C, Rouge, P, Samama, J.P. | | Deposit date: | 1997-09-15 | | Release date: | 1998-10-14 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the arcelin-1 dimer from Phaseolus vulgaris at 1.9-A resolution.
J.Biol.Chem., 273, 1998
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1BUL
 | | 6ALPHA-(HYDROXYPROPYL)PENICILLANATE ACYLATED ON NMC-A BETA-LACTAMASE FROM ENTEROBACTER CLOACAE | | Descriptor: | 2-(1-CARBOXY-2-HYDROXY-2-METHYL-PROPYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NMC-A BETA-LACTAMASE | | Authors: | Mourey, L, Swaren, P, Miyashita, K, Bulychev, A, Mobashery, S, Samama, J.P. | | Deposit date: | 1998-09-04 | | Release date: | 1998-12-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Inhibition of the Nmc-A B-Lactamase by a Penicillanic Acid Derivative, and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme
J.Am.Chem.Soc., 120, 1998
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1T5R
 | | STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN S COMPONENT FROM STAPHYLOCOCCUS AUREUS | | Descriptor: | LukS-PV | | Authors: | Guillet, V, Roblin, P, Keller, D, Prevost, G, Mourey, L. | | Deposit date: | 2004-05-05 | | Release date: | 2004-08-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of leucotoxin S component: new insight into the Staphylococcal beta-barrel pore-forming toxins.
J.Biol.Chem., 279, 2004
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1PVL
 | | STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN F COMPONENT FROM STAPHYLOCOCCUS AUREUS | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LEUCOCIDIN | | Authors: | Pedelacq, J.D, Mourey, L, Maveyraud, L, Prevost, G, Samama, J.P. | | Deposit date: | 1999-01-12 | | Release date: | 1999-06-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
Structure Fold.Des., 7, 1999
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6QBN
 | | structure of the core domaine of Knr4, an intrinsically disordered protein from Saccharomyces cerevisiae - mutant S200D | | Descriptor: | Cell wall assembly regulator SMI1 | | Authors: | Carivenc, C, Batista, M, Francois, J.M, Mourey, L, Maveyraud, L, Zerbib, D. | | Deposit date: | 2018-12-21 | | Release date: | 2020-01-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | structure of the core domaine of Knr4, an intrinsically disordered protein from Saccharomyces cerevisiae - mutant S200A
To Be Published
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6QBR
 | | structure of the core domaine of Knr4, an intrinsically disordered protein from Saccharomyces cerevisiae - mutant S200D, S203D | | Descriptor: | Cell wall assembly regulator SMI1 | | Authors: | Guillien, M, Batista, M, Francois, J.M, Mourey, L, Maveyraud, L, Zerbib, D. | | Deposit date: | 2018-12-21 | | Release date: | 2020-01-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | structure of the core domaine of Knr4, an intrinsically disordered protein from Saccharomyces cerevisiae - mutant S200D, S203D
To Be Published
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5NJI
 | | Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA | | Descriptor: | Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate | | Authors: | Gavalda, S, Faille, A, Mourey, L, Pedelacq, J.D. | | Deposit date: | 2017-03-28 | | Release date: | 2017-05-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
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2QK7
 | | A covalent S-F heterodimer of staphylococcal gamma-hemolysin | | Descriptor: | Gamma-hemolysin component A, Gamma-hemolysin component B | | Authors: | Roblin, P, Guillet, V, Maveyraud, L, Mourey, L. | | Deposit date: | 2007-07-10 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A covalent S-F heterodimer of leucotoxin reveals molecular plasticity of beta-barrel pore-forming toxins.
Proteins, 71, 2008
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5MTW
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5I0K
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8OTM
 | | structure of InhA from mycobacterium tuberculosis in complex with N-((1-(3-hydroxy-4-phenoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)-2-oxo-2H-chromene-3-carboxamide | | Descriptor: | 1,2-ETHANEDIOL, 2-oxidanylidene-~{N}-[[1-[(3-oxidanyl-4-phenoxy-phenyl)methyl]-1,2,3-triazol-4-yl]methyl]chromene-3-carboxamide, ACETATE ION, ... | | Authors: | Chebaiki, M, Maveyraud, L, Tamhaev, R, Lherbet, C, Mourey, L. | | Deposit date: | 2023-04-21 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Eur.J.Med.Chem., 259, 2023
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8OTN
 | | structure of InhA from mycobacterium tuberculosis in complex with inhibitor 7-((1-(3-Hydroxy-4-phenoxybenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methyl-2H-chromen-2-one | | Descriptor: | 4-methyl-7-[[1-[(3-oxidanyl-4-phenoxy-phenyl)methyl]-1,2,3-triazol-4-yl]methoxy]chromen-2-one, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Chebaiki, M, Maveyraud, L, Tamhaev, R, Lherbet, C, Mourey, L. | | Deposit date: | 2023-04-21 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.962 Å) | | Cite: | Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Eur.J.Med.Chem., 259, 2023
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8OTL
 | | structure of InhA from Mycobacterium tuberculosis in complex with 5-(((4-(2-hydroxyphenoxy)benzyl)(octyl)amino)methyl)-2-phenoxyphenol | | Descriptor: | 1,2-ETHANEDIOL, 5-[[octyl-[[4-(2-oxidanylphenoxy)phenyl]methyl]amino]methyl]-2-phenoxy-phenol, ACETATE ION, ... | | Authors: | Tamhaev, R, Maveyraud, L, Chebaiki, M, Lherbet, C, Mourey, L. | | Deposit date: | 2023-04-21 | | Release date: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.108 Å) | | Cite: | Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors.
Bioorg.Chem., 143, 2023
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5EY9
 | | Structure of FadD32 from Mycobacterium marinum complexed to AMPC12 | | Descriptor: | GLYCEROL, Long-chain-fatty-acid--AMP ligase FadD32, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl icosyl hydrogen phosphate | | Authors: | Guillet, V, Maveyraud, L, Mourey, L. | | Deposit date: | 2015-11-24 | | Release date: | 2015-12-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
J.Biol.Chem., 291, 2016
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5EY8
 | | Structure of FadD32 from Mycobacterium smegmatis complexed to AMPC20 | | Descriptor: | Acyl-CoA synthase, GLYCEROL, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl icosyl hydrogen phosphate | | Authors: | Guillet, V, Maveyraud, L, Mourey, L. | | Deposit date: | 2015-11-24 | | Release date: | 2015-12-16 | | Last modified: | 2016-04-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
J.Biol.Chem., 291, 2016
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7Q2F
 | | mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT585 | | Descriptor: | 1,2-ETHANEDIOL, 5,6-dimethyl-1~{H}-benzimidazol-2-amine, DIMETHYL SULFOXIDE, ... | | Authors: | Maveyraud, L, Galy, R, Mourey, L. | | Deposit date: | 2021-10-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis : A Crystallographic and Molecular Modelling Study.
Pharmaceuticals, 14, 2021
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7Q2H
 | | mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT275 | | Descriptor: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Hydroxymycolate synthase MmaA4, ... | | Authors: | Maveyraud, L, Galy, R, Mourey, L. | | Deposit date: | 2021-10-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis : A Crystallographic and Molecular Modelling Study.
Pharmaceuticals, 14, 2021
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7Q2D
 | | mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT320 | | Descriptor: | 1,2-ETHANEDIOL, 2-METHOXY-5-METHYLANILINE, DIMETHYL SULFOXIDE, ... | | Authors: | Maveyraud, L, Galy, R, Mourey, L. | | Deposit date: | 2021-10-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis : A Crystallographic and Molecular Modelling Study.
Pharmaceuticals, 14, 2021
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7Q2B
 | | mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT218 | | Descriptor: | 2-(phenylmethyl)imidazolidine, DIMETHYL SULFOXIDE, Hydroxymycolate synthase MmaA4, ... | | Authors: | Maveyraud, L, Galy, R, Mourey, L. | | Deposit date: | 2021-10-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis : A Crystallographic and Molecular Modelling Study.
Pharmaceuticals, 14, 2021
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7Q2G
 | | mycolic acid methyltransferase Hma (MmaA4) from Mycobac-terium tuberculosis in complex with ZT726 | | Descriptor: | 8-oxidanylquinoline-2-carbaldehyde, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Maveyraud, L, Galy, R, Mourey, L. | | Deposit date: | 2021-10-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis : A Crystallographic and Molecular Modelling Study.
Pharmaceuticals, 14, 2021
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7Q2C
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7Q2E
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5L84
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